Bats and viruses: a death-defying friendship.

Bats and viruses: a death-defying friendship.
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DOI:
10.1007/s13337-021-00716-0
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发表时间:
2021-09
期刊:
影响因子:
--
通讯作者:
Malik YS
Malik YS
中科院分区:
其他
文献类型:
--
作者:
Gupta P;Singh MP;Goyal K;Tripti P;Ansari MI;Obli Rajendran V;Dhama K;Malik YS

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蝙蝠有着原始的进化起源,并采取了各种各样的生存方式。它们在各种病毒性疾病的出现中发挥了核心作用。它们体内大量病毒种类的生存一直是一个认真的研究领域。这篇综述解释了蝙蝠病毒的进化如何与它们的代谢途径、飞行能力、繁殖能力和定殖行为联系在一起。DNA和RNA病毒对宿主免疫反应的利用是了解蝙蝠与其他哺乳动物病毒感染影响差异的开始。狂犬病病毒和其他狂犬病病毒作为蝙蝠病毒有很长的历史记录。虽然许多其他病毒,如埃博拉病毒,尼帕病毒,汉坦病毒,SARS冠状病毒,MERS冠状病毒和其他新出现的病毒,如苏苏加病毒,Menangle和Tioman病毒,现在正在广泛研究它们在新宿主中的传播。目前正在流行的SARS-CoV-2病毒也被认为起源于蝙蝠。某些因素已被链接到溢出事件,而在蝙蝠传播疾病的其他条件的权利范围仍然存在。然而,某些生理和生态参数已与特定的传播模式相关联,建立这些联系还有待更明确的证据。
Bats have a primeval evolutionary origin and have adopted various survival methods. They have played a central role in the emergence of various viral diseases. The sustenance of a plethora of virus species inside them has been an earnest area of study. This review explains how the evolution of viruses in bats has been linked to their metabolic pathways, flight abilities, reproductive abilities and colonization behaviors. The utilization of host immune response by DNA and RNA viruses is a commencement of the understanding of differences in the impact of viral infection in bats from other mammals. Rabies virus and other lyssa viruses have had long documented history as bat viruses. While many others like Ebola virus, Nipah virus, Hantavirus, SARS-CoV, MERS-CoV and other new emerging viruses like Sosuga virus, Menangle and Tioman virus are now being studied extensively for their transmission in new hosts. The ongoing pandemic SARS-CoV-2 virus has also been implicated to be originated from bats. Certain factors have been linked to spillover events while the scope of entitlement of other conditions in the spread of diseases from bats still exists. However, certain physiological and ecological parameters have been linked to specific transmission patterns, and more definite proofs are awaited for establishing these connections.
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