Catalytic stereoselective synthesis of highly substituted indanones via tandem nazarov cyclization and electrophilic fluorination trapping
Catalytic stereoselective synthesis of highly substituted indanones via tandem nazarov cyclization and electrophilic fluorination trapping
复制标题
通过串联纳扎罗夫环化和亲电氟化捕获催化立体选择性合成高度取代的茚满酮
DOI：
10.1021/ol071114j
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发表时间：
2007-08-02
期刊：
影响因子：
5.2
通讯作者：
Ma, Jun-An
中科院分区：
文献类型：
--
作者：
Nie, Jing;Zhu, Hong-Wei;Ma, Jun-An
通过Nazarov环化/亲电加成实现了一种新的催化立体选择性串联转化。该序列是有效地催化的Cu（II）配合物，以提供含氟的1-茚满酮衍生物具有两个新的立体中心，具有高的非对映选择性（反/顺高达49/1）。介绍了三个催化不对称串联转化的例子。
A new catalytic stereoselective tandem transformation via Nazarov cyclization/electrophilic fluorination has been accomplished. This sequence is efficiently catalyzed by a Cu(II) complex to afford fluorine-containing 1-indanone derivatives with two new stereocenters with high diastereoselectivity (trans/cis up to 49/1). Three examples of catalytic enantioselective tandem transformation are presented.