WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor
WSB-1, a novel IL-21 receptor binding molecule, enhances the maturation of IL-21 receptor
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DOI：
10.1016/j.cellimm.2011.03.010
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发表时间：
2011-01-01
影响因子：
4.3
通讯作者：
Asao, Hironobu
中科院分区：
文献类型：
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作者：
Nara, Hidetoshi;Onoda, Tadashi;Asao, Hironobu
白介素 21 (IL-21) 是一种多效细胞因子，可调节 T 细胞、B 细胞、NK 细胞和骨髓细胞功能。 IL-21 与其同源受体复合物结合，该复合物由 IL-21 受体 (IL-21R) 和共同的 γ 链组成。我们鉴定了一种新型 IL-21R 结合分子 WSB-1，它包含 WD-40 重复序列和 SOCS-box 结构域。 WSB-1与IL-21R胞质内区域的中部结合并促进IL-21R从N联糖基化形式向完全糖基化成熟形式的成熟。此外，WSB-1 可以减缓 IL-21R 的降解。综上所述，我们目前的研究表明 WSB-1 在调节 IL-21R 的成熟和降解中发挥作用。 (C) 2011 Elsevier Inc. 保留所有权利。
Interleukin-21 (IL-21) is a pleiotropic cytokine that regulates T-cell, B-cell, NK-cell, and myeloid-cell functions. IL-21 binds with its cognate receptor complex, which consists of the IL-21 receptor (IL-21R) and the common gamma chain. We identified a novel IL-21R-binding molecule, WSB-1, which contains WD-40 repeats and a SOCS-box domain. WSB-1 associates with the middle part of intracytoplasmic region of IL-21R and enhances the maturation of IL-21R from N-linked glycosylated form to fully glycosylated mature form. Furthermore, WSB-1 moderates IL-21R degradation. Taken together, our present study suggests that WSB-1 has a role in the tuning of the maturation and degradation of IL-21R. (C) 2011 Elsevier Inc. All rights reserved.