Phylogenetic characterization of H5N1 avian influenza viruses isolated in Indonesia from 2003-2007
Phylogenetic characterization of H5N1 avian influenza viruses isolated in Indonesia from 2003-2007
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DOI：
10.1016/j.virol.2009.04.024
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发表时间：
2009-07-20
期刊：
影响因子：
3.7
通讯作者：
Kawaoka, Yoshihiro
中科院分区：
文献类型：
--
作者：
Takano, Ryo;Nidom, Chairul A.;Kawaoka, Yoshihiro
H5 N1型高致病性禽流感病毒的广泛分布对人类健康构成了全球性威胁。印度尼西亚是这些病毒造成的人类感染和死亡人数最多的国家。为了了解病毒在印度尼西亚的地方流行状况，对2003年至2007年从家禽中分离的24株H5 N1病毒进行了遗传学特征分析。虽然以前的研究只将印度尼西亚病毒分为2.1.1-2.1.3分支，但我们的系统发育分析显示了一个新的亚系，不属于任何现有分支。此外，2005-2006年在爪哇岛发现了新的重组病毒，出现在这个新的亚系和其他分支之间。从2003年至2007年，H5 N1病毒多次从爪哇岛传入苏拉威西岛、加里曼丹岛和苏门答腊岛，导致这些病毒在印度尼西亚的地理扩张。这些发现确定爪哇岛是印度尼西亚H5 N1病毒扩散的中心。(C)2009 Elsevier Inc. All rights reserved.
The wide distribution of H5N1 highly pathogenic avian influenza viruses is a global threat to human health. Indonesia has had the largest number of human infections and fatalities caused by these viruses. To understand the enzootic conditions of the viruses in Indonesia, twenty-four H5N1 viruses isolated from poultry from 2003 to 2007 were phylogenetically characterized. Although previous studies exclusively classified the Indonesian viruses into clades 2.1.1-2.1.3, Our phylogenetic analyses showed a new sublineage that did not belong to any of the present clades. In addition, novel reassortant viruses were identified that emerged between this new sublineage and other clades in 2005-2006 on Java Island. H5N1 viruses were introduced from Java Island to Sulawesi, Kalimantan, and Sumatra Island on multiple occasions from 20032007, causing the geographical expansion of these viruses in Indonesia. These findings identify Java Island as the epicenter of the Indonesian H5N1 virus expansion. (C) 2009 Elsevier Inc. All rights reserved.