Model-based blood glucose control for Type 1 diabetes via parametric programming
Model-based blood glucose control for Type 1 diabetes via parametric programming
复制标题
DOI：
10.1109/tbme.2006.878075
复制
发表时间：
2006-08-01
影响因子：
4.6
通讯作者：
Pistikopoulos, Efstratios N.
中科院分区：
文献类型：
--
作者：
Dua, Pinky;Doyle, Francis J., III;Pistikopoulos, Efstratios N.
提出了一种用于调节1型糖尿病患者血糖的先进的基于模型的控制技术。最佳胰岛素输送速率是通过使用伦敦帝国理工学院开发的新型参数编程算法离线获得的，作为患者当前血糖浓度的显式函数。因此，最佳胰岛素输送速率的实现需要简单的函数评估和最小的在线计算。所提出的框架还解决了模型中的不确定性，由于患者间和患者内的变异性，通过确定模型参数，确保可以获得一个可行的控制律。本文报道的发展有望简化胰岛素给药机制，从而提高患者的生活质量。
An advanced model-based control technique for regulating the blood glucose for patients with Type 1 diabetes is presented. The optimal insulin delivery rate is obtained off-line as an explicit function of the current blood glucose concentration of the patient by using novel parametric programming algorithms, developed at Imperial College London. The implementation of the optimal insulin delivery rate, therefore, requires simple function evaluation and minimal on-line computations. The proposed framework also addresses the uncertainty in the model due to interpatient and intrapatient variability by identifying the model parameters which ensure that a feasible control law can be obtained. The developments reported in this paper are expected to simplify the insulin delivery mechanism, thereby enhancing the quality of life of the patient.