CIRCULATING IMMUNE-COMPLEXES IN GIANT-CELL ARTERITIS AND POLYMYALGIA RHEUMATICA
CIRCULATING IMMUNE-COMPLEXES IN GIANT-CELL ARTERITIS AND POLYMYALGIA RHEUMATICA
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DOI：
10.1002/art.1780230909
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发表时间：
1980-01-01
影响因子：
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通讯作者：
MCDUFFIE, FC
中科院分区：
文献类型：
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作者：
PAPAIOANNOU, CC;GUPTA, RC;MCDUFFIE, FC
用Raji细胞放射免疫分析法检测了74例风湿性多肌痛或巨细胞动脉炎或两者兼有的患者血清免疫复合物。活动性疾病患者的水平高于非活动性疾病患者。单纯风湿性多肌痛患者和巨细胞动脉炎患者的免疫复合物样物质水平无差异。1份血清的密度梯度分析显示免疫复合物样物质主要在19S [Svedberg单位]区域。免疫复合物在这些疾病的发病机制中可能是重要的。
Sera from 74 patients with polymyalgia rheumatica or giant cell arteritis or both were tested for immune complexes by using the Raji cell radioimmunoassay. Levels in patients with active disease were higher than in patients whose disease was inactive. There was no difference in levels of immune complex-like materials between patients with polymyalgia rheumatica alone and those with giant cell arteritis. Density gradient analysis of 1 serum showed immune complex-like materials mainly in the 19S [Svedberg unit] region. Immune complexes may be important in the pathogenesis of these conditions.