Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion
Functional IL-4 receptors on mouse astrocytes: IL-4 inhibits astrocyte activation and induces NGF secretion
复制标题
DOI：
10.1016/s0165-5728(97)00154-9
复制
发表时间：
1998-01-01
影响因子：
3.3
通讯作者：
Kazimirsky, G
中科院分区：
文献类型：
--
作者：
Brodie, C;Goldreich, N;Kazimirsky, G
IL-4是Th 2衍生的细胞因子，其在各种免疫活性细胞的功能中以及在各种CNS病症的病理生理学中起重要作用。在这项研究中，我们的特点是在培养的星形胶质细胞中的IL-4 R的表达，并探讨IL-4对这些细胞的功能的影响。我们发现星形胶质细胞表达IL-4 R的膜结合和可溶形式的mRNA，而它们不分泌IL-4。IL-4抑制LPS刺激诱导的NO生成和iNOS表达，并降低TNF-α的分泌和ICAM-1的表达。相反，IL-4诱导星形胶质细胞分泌NGF，并与LPS和TNF-α协同作用。这些结果表明，IL-4在中枢神经系统中作为免疫抑制和神经营养因子的重要作用。(C)1998年Elsevier Science B.V.
IL-4 is a Th2-derived cytokine which plays an important role in the function of various immunocompetent cells as well as in the pathophysiology of various CNS disorders. In this study we characterized the expression of IL-4R in cultured astrocytes and explored the effects of IL-4 on the function of these cells. We found that astrocytes express the mRNA of both the membrane-hound and the soluble forms of the IL-4R, whereas they do not secrete IL-4. IL-4 inhibited both NO production and iNOS expression induced by LPS stimulation and decreased the secretion of TNF-alpha and the expression of ICAM-1. In contrast, IL-4 induced the secretion of NGF by astrocytes and synergized with LPS and TNF-alpha in this effect. These results suggest an important role for IL-4 as an immunosuppressive and a neurotrophic factor in the CNS. (C) 1998 Elsevier Science B.V.