Contractile mechanisms of canine colonic propulsion.
Contractile mechanisms of canine colonic propulsion.
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DOI：
10.1152/ajpgi.1995.268.3.g530
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发表时间：
1995-03
期刊：
影响因子：
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通讯作者：
A. Sethi;Sushil K. Sarna
中科院分区：
文献类型：
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作者：
A. Sethi;Sushil K. Sarna
我们研究了狗结肠推进的收缩机制。“传播指数”表明尾部或orad传播的收缩状态表现出最强的相关性与过境期间的空腹和餐后状态。其他参数，如收缩状态的总持续时间和收缩面积，也有助于运输，但程度较低。所有参数表现出更强的相关性，过境期间空腹比餐后状态。在禁食状态下，传输速率在近端比在中间结肠快。餐后状态下，通过近端结肠和中结肠的传输率呈线性。与阶段性收缩和收缩状态相反，巨大的迁移性收缩是超推进的。我们的结论是，在结肠的收缩状态的传播是一个主要因素，在缓慢的净远端推进结肠内容。单独的阶段性收缩可主要产生结肠内容物的混合和搅动。巨大的迁移性收缩迅速地将结肠内容物推进很长的距离。
We investigated the contractile mechanisms of propulsion in the dog colon. "Propagation index" indicating caudad or orad propagation of contractile states exhibited the strongest correlation with transit during both the fasting and the postprandial states. Other parameters, such as total duration of contractile states and area under contractions, also contributed to transit, but to a lesser degree. All parameters exhibited a stronger correlation with transit during the fasting than during the postprandial state. During the fasting state, the transit rate was faster in the proximal than in the middle colon. The transit rate was linear through the proximal and the middle colon during the postprandial state. In contrast to the phasic contractions and the contractile states, the giant migrating contractions were ultrapropulsive. We conclude that the propagation of contractile states in the colon is a major factor in the slow net distal propulsion of colonic contents. The individual phasic contractions may mainly produce mixing and agitation of colonic contents. Giant migrating contractions rapidly propel colonic contents over long distances.