Two fast transient current components during voltage clamp on snail neurons.
Two fast transient current components during voltage clamp on snail neurons.
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DOI：
10.1085/jgp.58.1.36
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发表时间：
1971-07
影响因子：
3.8
通讯作者：
Neher, E
中科院分区：
文献类型：
--
作者：
Neher, E
来自中等大小的Haplanpomatia神经节细胞的电压钳电流除了通常观察到的内向和外向电流外，还具有快速瞬态外向电流分量。该成分在正常静息电位下失活。的电流，这是由K+离子进行，可能超过泄漏电流的一个因素的100后，失活已被删除的超极化条件脉冲。它的动力学类似于内向电流，除了它具有更长的失活时间常数。它的阈值接近静息电位。这种额外的成分也存在于巨细胞中，然而，它不那么突出。起搏器活动由该电流控制。结果发现，内向电流除了快速的Hodgkin-Huxley型失活外，还有一个缓慢的失活过程。慢过程的时间常数与慢外向电流失活的时间常数相似。
Voltage clamp currents from medium sized ganglion cells of Helix pomatia have a fast transient outward current component in addition to the usually observed inward and outward currents. This component is inactivated at normal resting potential. The current, which is carried by K+ ions, may surpass leakage currents by a factor of 100 after inactivation has been removed by hyperpolarizing conditioning pulses. Its kinetics are similar to those of the inward current, except that it has a longer time constant of inactivation. It has a threshold close to resting potential. This additional component is also present in giant cells, where however, it is less prominent. Pacemaker activity is controlled by this current. It was found that inward currents have a slow inactivating process in addition to a fast, Hodgkin-Huxley type inactivation. The time constants of the slow process are similar to those of slow outward current inactivation.