SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation.
SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation.
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DOI：
10.3389/fphys.2015.00046
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发表时间：
2015
影响因子：
4
通讯作者：
Ai X
中科院分区：
文献类型：
--
作者：
Ai X
心房颤动（AF）是最常见的持续性心律失常。它与栓塞性中风引起的过早死亡风险显著增加有关，并使共存的心血管疾病（如心力衰竭）复杂化。房颤的患病率随着年龄的增长而急剧增加，老龄化已被证明是房颤的独立风险。由于世界人口老龄化，越来越多的房颤患者生活质量下降，并造成相关的经济负担。然而，由于对房颤在衰竭和/或衰老心脏中的分子和电生理机制了解不足，缺乏有效的药物治疗和预防策略。最近的研究表明，心房钙处理的改变有助于房颤的发生和维持。在这里，我们回顾了应激反应激酶和钙处理功能障碍在老年和心力衰竭房颤发生中的作用。
Atrial fibrillation (AF) is the most common sustained arrhythmia. It is associated with a markedly increased risk of premature death due to embolic stroke and also complicates co-existing cardiovascular diseases such as heart failure. The prevalence of AF increases dramatically with age, and aging has been shown to be an independent risk of AF. Due to an aging population in the world, a growing body of AF patients are suffering a diminished quality of life and causing an associated economic burden. However, effective pharmacologic treatments and prevention strategies are lacking due to a poor understanding of the molecular and electrophysiologic mechanisms of AF in the failing and/or aged heart. Recent studies suggest that altered atrial calcium handling contributes to the onset and maintenance of AF. Here we review the role of stress-response kinases and calcium handling dysfunction in AF genesis in the aged and failing heart.
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