Surface-coil-type resonators for in vivo temporal ESR measurements in different organs of nitroxide-treated rats
Surface-coil-type resonators for in vivo temporal ESR measurements in different organs of nitroxide-treated rats
复制标题
用于测量硝基氧治疗大鼠不同器官体内时间 ESR 的表面线圈型谐振器
DOI：
10.1007/bf03162304
复制
发表时间：
2000
影响因子：
1
通讯作者：
T. Ogata
中科院分区：
文献类型：
--
作者：
M. Tada;H. Yokoyama;Y. Toyoda;H. Ohya;Tomohiro Ito;T. Ogata
Three kinds of surface-coil-type resonators (SCRs) operating at 720 MHz were fabricated for in vivo temporal electron spin resonance (ESR) measurements. The inner diameter of the singleturn coil of the SCRs was 3, 4, or 10 mm. ResonatorQincreases and the detection limit decreases with coil diameter. The distance across which the microwave magnetic field can penetrate in the direction facing to the coil was about the same (about 2 mm) for all SCRs. In vivo kinetic studies of intravenously injected 4-hydroxy-2,2,6,6-tetramethylpiperidin-l-oxyl (TEMPOL) were performed at the liver, kidney, stomach, rectum, vein, and skin of rats with SCRs suited to the target areas. The halflife of TEMPOL was estimated from the exponential decay of the ESR signal intensity (the peak-to-peak height). Different sites in the rat showed apparent differences in the half-life of TEMPOL. This suggests that the apparent differences in the reducing ability of TEMPOL are related to the organ or tissue where measurement is taken because no excretion of TEMPOL was observed.
