The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland.
The role of mammary stroma in modulating the proliferative response to ovarian hormones in the normal mammary gland.
复制标题
乳腺基质在调节正常乳腺中卵巢激素的增殖反应中的作用。
DOI：
10.1023/a:1018738721656
复制
发表时间：
1998
影响因子：
2.5
通讯作者：
Haslam,SZ
中科院分区：
文献类型：
--
作者：
Woodward,TL;Xie,JW;Haslam,SZ
出生后乳腺发育高度依赖于卵巢类固醇激素、雌激素和孕激素。然而，来自体外和体内研究的证据表明，类固醇诱导的发育是间接发生的，需要上皮细胞增殖和形态发生中的基质合作。基质细胞似乎通过分泌生长因子和/或改变上皮细胞所处的细胞外基质的组成来影响上皮细胞的行为。本文就卵巢发育过程中对基质组织的需求以及EGF、IGF、HGF和FGF 3等生长因子家族在调节卵巢增殖反应中的作用作一综述。此外，细胞外基质蛋白，包括纤维连接蛋白，胶原和层粘连蛋白的作用，将被总结。
Postnatal mammary gland development is highlydependent on the ovarian steroids, estrogen andprogesterone. However, evidence from both in vitro andin vivo studies indicates that steroid-induceddevelopment occurs indirectly, requiring stromalcooperation in epithelial proliferation andmorphogenesis. Stromal cells appear to influenceepithelial cell behavior by secretion of growth factorsand/or by altering the composition of the extracellular matrix inwhich epithelial cells reside. This review will discussthe requirement for stromal tissue in modulatingproliferative responses to ovarian hormones during postnatal development and the potential role ofthe EGF, IGF, HGF and FGF3growth factorfamilies. Additionally, the roles of extracellularmatrix proteins, including fibronectin, collagens andlaminin, will be summarized.