Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease
Longitudinal Changes in Individual BrainAGE in Healthy Aging, Mild Cognitive Impairment, and Alzheimer's Disease
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DOI：
10.1024/1662-9647/a000074
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发表时间：
2012-12-01
影响因子：
1
通讯作者：
Gaser, Christian
中科院分区：
文献类型：
--
作者：
Franke, Katja;Gaser, Christian
我们最近提出了一种新的方法，将整个大脑的多维衰老模式聚合到一个单一的值。事实证明，这种方法提供了稳定可靠的脑老化估计——即使在不同的扫描仪上也是如此。在对大约400名老年受试者进行脑年龄纵向变化调查时，我们发现阿尔茨海默病患者和在3年内转化为ad的受试者在基线时脑萎缩加速了6年。在随访期间，BrainAGE的额外增加累积到约+ 9年的分数。脑老化加速与预期的认知能力下降和疾病严重程度有关。总之，BrainAGE框架表明了大脑衰老的差异，因此可以作为未来认知功能的指标。
We recently proposed a novel method that aggregates the multidimensional aging pattern across the brain to a single value. This method proved to provide stable and reliable estimates of brain aging - even across different scanners. While investigating longitudinal changes in BrainAGE in about 400 elderly subjects, we discovered that patients with Alzheimer's disease and subjects who had converted toADwithin 3 years showed accelerated brain atrophy by + 6 years at baseline. An additional increase in BrainAGE accumulated to a score of about + 9 years during follow-up. Accelerated brain aging was related to prospective cognitive decline and disease severity. In conclusion, the BrainAGE framework indicates discrepancies in brain aging and could thus serve as an indicator for cognitive functioning in the future.