GATA3 in development and cancer differentiation: cells GATA have it!
GATA3 in development and cancer differentiation: cells GATA have it!
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DOI：
10.1002/jcp.21943
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发表时间：
2010-01
影响因子：
5.6
通讯作者：
Werb, Zena
中科院分区：
文献类型：
--
作者：
Chou, Jonathan;Provot, Sylvain;Werb, Zena
越来越多的证据表明，在正常发育过程中调节细胞分化的多种机制也参与了肿瘤的发生。在乳腺癌中，对原发肿瘤表达的分化标志物进行常规分析以指导临床决策。事实上，大量研究表明分化谱与肿瘤的转移潜能有关。转录因子GATA3最近被认为是人类腔内乳腺癌临床结果的一个强有力的预测因子。在乳腺中，GATA3是管腔上皮细胞分化和承诺所必需的，随着癌细胞获得干细胞样表型，其表达在管腔乳腺癌进展过程中逐渐丧失。重要的是，在小鼠模型中，GATA3阴性、未分化的乳腺癌细胞中表达GATA3足以诱导肿瘤分化并抑制肿瘤播散。这些发现证明了一种分化因子影响恶性性质的精妙能力，并提出了GATA3或其下游基因可用于治疗腔内乳腺癌的可能性。这篇综述强调了我们最近对GATA3在正常乳腺发育和肿瘤分化中的认识。
There is increasing evidence that the numerous mechanisms that regulate cell differentiation during normal development are also involved in tumorigenesis. In breast cancer, differentiation markers expressed by the primary tumor are routinely profiled to guide clinical decisions. Indeed, numerous studies have shown that the differentiation profile correlates with the metastatic potential of tumors. The transcription factor GATA3 has emerged recently as a strong predictor of clinical outcome in human luminal breast cancer. In the mammary gland, GATA3 is required for luminal epithelial cell differentiation and commitment, and its expression is progressively lost during luminal breast cancer progression as cancer cells acquire a stem cell-like phenotype. Importantly, expression of GATA3 in GATA3-negative, undifferentiated breast carcinoma cells is sufficient to induce tumor differentiation and inhibits tumor dissemination in a mouse model. These findings demonstrate the exquisite ability of a differentiation factor to affect malignant properties, and raise the possibility that GATA3 or its downstream genes could be used in treating luminal breast cancer. This review highlights our recent understanding of GATA3 in both normal mammary development and tumor differentiation.
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影响因子：
4.5
作者：
Grote D;Boualia SK;Souabni A;Merkel C;Chi X;Costantini F;Carroll T;Bouchard M
通讯作者：
Bouchard M
DOI：
10.1186/bcr1617
发表时间：
2006
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Abba MC;Nunez MI;Colussi AG;Croce MV;Segal-Eiras A;Aldaz CM
通讯作者：
Aldaz CM
影响因子：
11.8
作者：
Gregory, Brian D.;O'Malley, Ronan C.;Ecker, Joseph R.
通讯作者：
Ecker, Joseph R.
影响因子：
4.4
作者：
Hong, Seok Jong;Choi, Hyun Jin;Kim, Kwang-Soo
通讯作者：
Kim, Kwang-Soo
影响因子：
9.2
作者：
Blokzijl, A;ten Dijke, P;Ibáñez, CF
通讯作者：
Ibáñez, CF