Crocetin: an agent derived from saffron for prevention and therapy for cancer.
Crocetin: an agent derived from saffron for prevention and therapy for cancer.
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DOI：
10.2174/138920112798868566
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发表时间：
2012-01
影响因子：
2.8
通讯作者：
Dhar A
中科院分区：
文献类型：
--
作者：
Gutheil WG;Reed G;Ray A;Anant S;Dhar A
癌症是美国的主要死亡原因之一，每年在全世界造成约800万人死亡。虽然癌症患者有越来越多的治疗选择，但其疗效是有时间限制的和非治愈性的。在美国，大约50-60%的癌症患者使用来自植物不同部分或营养素的药剂（补充和替代医学），单独或与传统治疗方案如化疗和/或放疗同时使用。对新药的需求促使人们研究评估水果、蔬菜、草药和香料中可能的抗癌剂。藏红花，一种存在于植物番红花（Crocus sativus L.）的干柱头中的香料和食用着色剂，在古代阿拉伯、印度和中国文化中，它被用作治疗各种疾病的草药，包括癌症。藏红花酸是藏红花中重要的类胡萝卜素成分，在动物模型和细胞培养系统中显示出作为抗肿瘤剂的显著潜力。西红花酸通过抑制核酸合成、增强抗氧化系统、诱导细胞凋亡、阻断生长因子信号通路等途径影响癌细胞的生长。本文综述了西红花酸的抗癌作用及其应用前景。
Cancer is one of the leading causes of death in the United States and accounts for approximately 8 million deaths per year worldwide. Although there is an increasing number of therapeutic options available for patients with cancer, their efficacy is time-limited and non-curative. Approximately 50-60% of cancer patients in the United States utilize agents derived from different parts of plants or nutrients (complementary and alternative medicine), exclusively or concurrently with traditional therapeutic regime such as chemotherapy and/or radiation therapy. The need for new drugs has prompted studies evaluating possible anti-cancer agents in fruits, vegetables, herbs and spices. Saffron, a spice and a food colorant present in the dry stigmas of the plant Crocus sativus L., has been used as an herbal remedy for various ailments including cancer by the ancient Arabian, Indian and Chinese cultures. Crocetin, an important carotenoid constituent of saffron, has shown significant potential as an anti-tumor agent in animal models and cell culture systems. Crocetin affects the growth of cancer cells by inhibiting nucleic acid synthesis, enhancing anti-oxidative system, inducing apoptosis and hindering growth factor signaling pathways. This review discusses the studies on cancer preventive potential of crocetin and its future use as an anticancer agent.