Salvage Re-irradiation with Intensity-modulated Radiotherapy, Chemotherapy Combined with Hyperthermia for Local Recurrence of Nasopharyngeal Carcinoma After Chemoradiotherapy
Salvage Re-irradiation with Intensity-modulated Radiotherapy, Chemotherapy Combined with Hyperthermia for Local Recurrence of Nasopharyngeal Carcinoma After Chemoradiotherapy
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DOI：
10.7888/juoeh.43.355
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发表时间：
2021-09-01
期刊：
影响因子：
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通讯作者：
Korogi, Yukunori
中科院分区：
文献类型：
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作者：
Morisaki, Takahiro;Ohguri, Takayuki;Korogi, Yukunori
由于对危险器官的剂量限制，在放疗后局部复发的癌症的再照射中难以给予足够剂量的辐射。再照射病例还包括局部难以控制的放射抗性肿瘤，其预后一般较差。最近有报道称，使用调强放疗（IMRT）进行再照射的效果可显著降低危及器官的剂量，并且有报道称热疗对放射抗性肿瘤具有疗效。我们报告了一例鼻咽癌患者在同步放化疗后局部复发的病例，采用调强放疗和化疗联合热疗进行补救性再照射，并包括文献讨论。
A sufficient dose of radiation is difficult to administer in re-irradiation for local recurrence of cancer after radiotherapy because of the dose limitation to organs at risk. Re-irradiation cases also include radioresistant tumors that are difficult to control locally, and their prognosis is poor in general. The effect of re-irradiation using intensity-modulated radiotherapy (IMRT) has recently been reported to significantly reduce the dose to organs at risk, and the efficacy of hyperthermia has been reported for radioresistant tumors. We report a case of local recurrence after concurrent chemoradiotherapy treated with salvage re-irradiation using IMRT and chemotherapy combined with hyperthermia in a patient with nasopharyngeal carcinoma, and include a discussion of the literature.