Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas
Various immunostaining patterns of CD31, CD34 and endoglin and their relationship with lymph node metastasis in oral squamous cell carcinomas
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DOI：
10.1111/j.1600-0714.2004.00227.x
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发表时间：
2005-02-01
影响因子：
3.3
通讯作者：
Nagai, N
中科院分区：
文献类型：
--
作者：
Nagatsuka, H;Hibi, K;Nagai, N
背景：肿瘤内血管在肿瘤生长和转移中起重要作用。在以前的报告中使用不同的内皮标记物的差异建议我们用广泛的血管标记物来研究正常和各种肿瘤区域。以CD31、CD34和endoglin作为血管标记物，研究口腔正常组织和鳞癌组织中血管的分布和性质。在癌细胞巢和癌浸润的边缘区存在大量重塑活性强的微血管以及未分化的肿瘤血管内皮细胞和未成熟的内皮细胞。我们的研究结果显示，不同的免疫组化标记在正常和肿瘤组织中的血管分布模式不同。结论：血管分布和内皮细胞的性质似乎与转移密切相关。
BACKGROUND: Intratumoral blood vessels are known to play an important role in cancer growth and metastasis. The discrepancy in previous reports using various endothelial markers individually suggested us to investigate both normal and various tumor areas with a wide panel of vascular markers.METHODS: Here, we used a panel of three antibodies (CD31, CD34, and endoglin) as blood vessel markers to investigate the distribution and properties of blood vessels in normal oral tissues and squamous cell carcinomas.RESULTS: Many microvessels with strong remodeling activity as well as undifferentiated tumoral vascular endothelial cells and immature endothelial cells were present in the cancer cell nest and marginal area of cancer infiltration. Our results showed different vascular distribution patterns using various immunostaining markers in normal and tumoral tissues.CONCLUSION: Vascular distribution and properties of endothelial cells appear to be closely associated with metastasis.