Effects of diabetes mellitus on salivary secretion and its composition in the human
Effects of diabetes mellitus on salivary secretion and its composition in the human
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DOI：
10.1023/b:mcbi.0000028748.40917.6f
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发表时间：
2004-06-01
影响因子：
4.3
通讯作者：
Singh, J
中科院分区：
文献类型：
--
作者：
Mata, AD;Marques, D;Singh, J
这项研究调查了糖尿病(I型和II型)对人类唾液腺功能的影响，并与年龄匹配的健康对照组进行了比较。结果表明，与年龄匹配的健康对照组(AMC)相比，I型和II型糖尿病患者的静息和刺激唾液分泌都显著减少(p<；0.05)。研究还发现，与健康受试者相比，糖尿病患者的静息和刺激唾液蛋白浓度增加。然而，与对照组相比，分泌能力(刺激减去静息值)显著降低。与AMC相比，糖尿病患者唾液中钙离子水平显著升高(p<；0.05)。相比之下，糖尿病患者唾液中镁(镁)、锌(锌)和钾(K+)的水平与AMC的值相比显著降低(p<；0.05)。这些结果表明，糖尿病可导致唾液腺分泌能力的明显功能障碍。在这些患者中，改良的液体、有机和无机唾液分泌物可能是文献中其他人所描述的口腔感染易感性增加和伤口愈合受损的原因。
This study investigated the effects of diabetes mellitus (types I and II) on human salivary gland function compared to healthy age-matched controls. The results have shown that both type I and type II diabetic patients secrete significantly (p < 0.05) less resting and stimulated saliva compared to healthy age-matched controls (AMC). It was also found that the diabetic patients have an increased resting and stimulated salivary protein concentration compared to healthy participants. However, the secretory capacity (stimulated minus resting values) was markedly reduced compared to controls. The level of calcium (Ca2+) in the saliva of diabetic patients was significantly (p < 0.05) elevated compared to the AMC. In contrast, the levels of magnesium (Mg2+), zinc (Zn2+) and potassium (K+) in the saliva of diabetic patients were significantly (p < 0.05) reduced compared to the values obtained in AMC. These results indicate that diabetes mellitus can lead to marked dysfunction of the secretory capacity of the salivary glands. In these patients a modified fluid, organic and inorganic salivary secretion may be responsible for the increased susceptibility to oral infections and impaired wound healing described by others in the literature.