Neural basis of imprinting behavior in chicks.
Neural basis of imprinting behavior in chicks.
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雏鸡印记行为的神经基础。
DOI：
10.1111/dgd.12028
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Tomoharu Nakamori
中科院分区：
文献类型：
--
作者：
浜崎 浩子;前川文彦;Tomoharu Nakamori
新孵化的雏鸟会记住它们遇到的第一个移动物体的特征，并随后表现出对它的偏好。这种“印记”行为是婴儿学习的一个例子，是由视觉和/或听觉线索引起的。雏鸡印记刺激的视觉信息首先在与哺乳动物视觉皮质相对应的端脑区--视髓(VW)中处理，聚集在大脑皮层致密上皮层(HDCo)细胞的核心区，然后传递到中间内侧系膜(IMM)，该区域类似于哺乳动物的联结皮质。印记记忆存储在IMM中，通过印记改变IMM神经元的活动。印记还可以诱导连接大众和免疫内侧核的回路中神经元的功能和结构的可塑性变化。在这些神经元中，HDCo细胞的活动受到印记的强烈影响。含NR2B亚单位的N-甲基-D-天冬氨酸(NMDA)受体在HDCo细胞中的表达和调控对该回路的可塑性变化以及视觉印迹过程至关重要。因此，阐明HDCo细胞发生可塑性变化的细胞和分子机制可能为婴儿学习提供有用的知识。
Newly hatched chicks memorize the characteristics of the first moving object they encounter, and subsequently show a preference for it. This “imprinting” behavior is an example of infant learning and is elicited by visual and/or auditory cues. Visual information of imprinting stimuli in chicks is first processed in the visual Wulst (VW), a telencephalic area corresponding to the mammalian visual cortex, congregates in the core region of the hyperpallium densocellulare (HDCo) cells, and transmitted to the intermediate medial mesopallium (IMM), a region similar to the mammalian association cortex. The imprinting memory is stored in the IMM, and activities of IMM neurons are altered by imprinting. Imprinting also induces functional and structural plastic changes of neurons in the circuit that links the VW and the IMM. Of these neurons, the activity of the HDCo cells is strongly influenced by imprinting. Expression and modulation of NR2B subunit‐containing N‐methyl‐D‐aspartate (NMDA) receptors in the HDCo cells are crucial for plastic changes in this circuit as well as the process of visual imprinting. Thus, elucidation of cellular and molecular mechanisms underlying the plastic changes that occurred in the HDCo cells may provide useful knowledge about infant learning.