Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval.
Activation of perineuronal net-expressing excitatory neurons during associative memory encoding and retrieval.
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DOI：
10.1038/srep46024
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发表时间：
2017-04-05
影响因子：
4.6
通讯作者：
Tamura H
中科院分区：
文献类型：
--
作者：
Morikawa S;Ikegaya Y;Narita M;Tamura H
神经周围网（PNNs）是一种富含蛋白聚糖的细胞外基质结构，被认为在抑制性神经元周围表达，并参与脑功能和突触可塑性的关键时期。然而，在一些特定的大脑区域，如杏仁核，pnn主要在兴奋性神经元周围表达。这些神经元在听觉恐惧条件反射和记忆提取过程中被招募。事实上，表达pnn的兴奋性神经元的激活预测了认知表现。
Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.