Omega-3 fatty acids and supportive psychotherapy for perinatal depression: A randomized placebo-controlled study
Omega-3 fatty acids and supportive psychotherapy for perinatal depression: A randomized placebo-controlled study
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DOI：
10.1016/j.jad.2007.12.228
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发表时间：
2008-09-01
影响因子：
6.6
通讯作者：
Gelenberg, Alan J.
中科院分区：
文献类型：
--
作者：
Freeman, Marlene P.;Davis, Melinda;Gelenberg, Alan J.
背景：围产期抑郁症（MDD），包括产前和产后抑郁症，是常见的，并有严重的后果。本研究的目的是调查的可行性，安全性和有效性的omega-3脂肪酸围产期抑郁症除了支持性psychotherapy.Methods：围产期妇女与抑郁症随机二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），1.9g/天，或安慰剂8周。为所有受试者提供手动支持性心理治疗。症状进行了评估与汉密尔顿抑郁量表（HAM-D）和爱丁堡产后抑郁量表（EPDS）biweekly.Results：59名妇女入组; N = 51有两个数据收集点，允许评估疗效。Omega-3脂肪酸耐受性良好。两组参与者的EPDS和HAM-D评分均较基线显著降低（P <0.0001）。我们没有发现omega-3脂肪酸比安慰剂更有益。饮食中的ω-3脂肪酸摄入量低的参与者。局限性：检测ω-3脂肪酸的影响的能力可能受到样本量，研究长度或剂量的限制。支持性心理治疗的好处可能有限制的能力来检测的效果的omega-3 fatty acids.Conclusions：在这项研究中，所有参与者接受支持性心理治疗的omega-3脂肪酸和安慰剂之间没有显着差异。手册化的支持性心理治疗值得进一步研究。考虑到在子宫内和婴儿中广泛确立的健康优势，参与者中膳食ω-3脂肪酸的低摄入量令人担忧。(C)2007 Elsevier B. V.保留所有权利。
Background: Perinatal major depressive disorder (MDD), including antenatal and postpartum depression, is common and has serious consequences. This study was designed to investigate the feasibility, safety, and efficacy of omega-3 fatty acids for perinatal depression in addition to supportive psychotherapy.Methods: Perinatal women with MDD were randomized to eicosapentacnoic (EPA) and docosahexaenoic acids (DHA), 1.9g/day, or placebo for 8weeks. A manualized supportive psychotherapy was provided to all subjects. Symptoms were assessed with the Hamilton Rating Scale for Depression (HAM-D) and Edinburgh Postnatal Depression Scale (EPDS) biweekly.Results: Fifty-nine women enrolled; N = 51 had two data collection points that allowed for evaluation of efficacy. Omega-3 fatty acids were well tolerated. Participants in both groups experienced significant decreases in EPDS and HAM-D scores (P < .0001) from baseline. We did not find a benefit of omega-3 fatty acids over placebo. Dietary omega-3 fatty acid intake was low among participants.Limitations: The ability to detect an effect of omega-3 fatty acids may have been limited by sample size, study length, or dose. The benefits of supportive psychotherapy may have limited the ability to detect an effect of omega-3 fatty acids.Conclusions: There was no significant difference between omega-3 fatty acids and placebo in this study in which all participants received supportive psychotherapy. The manualized supportive psychotherapy warrants further study. The low intake of dietary omega-3 fatty acids among participants is of concern, in consideration of the widely established health advantages in utero and in infants. (C) 2007 Elsevier B.V. All rights reserved.