The Hippocampus Contributes to Memory Expression During Transitive Inference in Mice
The Hippocampus Contributes to Memory Expression During Transitive Inference in Mice
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DOI：
10.1002/hipo.20610
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发表时间：
2010-01-01
期刊：
影响因子：
3.5
通讯作者：
Eichenbaum, Howard
中科院分区：
文献类型：
--
作者：
DeVito, Loren M.;Kanter, Benjamin R.;Eichenbaum, Howard
有大量证据表明，海马体在传递推理中发挥着作用，这种能力将重叠的记忆联系起来，然后在那些只是间接相关的记忆元素之间做出新的判断。然而，海马体是否主要参与重叠记忆的原始获取，还是在传递性判断过程中参与这些记忆的灵活表达，目前尚不清楚。在这里，我们证明了在获得重叠记忆后产生的选择性海马损伤导致随后的传递推理判断严重受损，这表明海马在初始学习阶段之后确实发挥了重要作用。此外，本研究将海马在传递推理中的作用扩展到小鼠，正如之前在其他物种中观察到的那样。(C) 2009 Wiley-Liss, Inc。
There is substantial evidence that the hippocampus plays a role in transitive inference, the capacity to link overlapping memories and subsequently make novel judgments between elements of those memories that are only indirectly related. However, it is unclear whether the hippocampus is involved primarily during the original acquisition of the overlapping memories, or additionally during the flexible expression of those memories during transitive judgments. Here, we demonstrated that selective hippocampal damage produced after acquisition of the overlapping memories resulted in a severe impairment in subsequent transitive inference judgments, indicating that the hippocampus does play an important role beyond the initial learning phase. Furthermore, this study extends to mice a role for the hippocampus in transitive inference, as previously observed in other species. (C) 2009 Wiley-Liss, Inc.