Hysteresis-free and high sensitivity strain sensing of ionically conductive hydrogels.
Hysteresis-free and high sensitivity strain sensing of ionically conductive hydrogels.
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离子导电水凝胶的无滞后和高灵敏度应变传感。
DOI：
10.1002/anbr.202200132
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发表时间：
2022-12
影响因子：
3.4
通讯作者：
Jiwoo Song;Chenchen Mou;G. Balakrishnan;Yingqiao Wang;Mahathy Rajagopalan;Audrey Schreiner;Durva Naik;Tzahi Cohen-Karni;M. S. Halbreiner;C. Bettinger
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文献类型：
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作者：
Jiwoo Song;Chenchen Mou;G. Balakrishnan;Yingqiao Wang;Mahathy Rajagopalan;Audrey Schreiner;Durva Naik;Tzahi Cohen-Karni;M. S. Halbreiner;C. Bettinger
与其他聚合物网络相比，水凝胶具有较大的顺应性（E500%），因此是一种有前途的柔软和可植入应变传感器材料。此外，水凝胶可以被功能化以与许多类型的组织无缝整合。然而，目前大多数方法试图通过掺入具有正交性质（如电子或混合离子传导）的填料来向结构水凝胶材料注入额外的电子功能。虽然复合材料策略可以提高性能或促进与下游硬件的异构集成，但复合材料使监管批准的路径复杂化，并且可能损害底层结构材料的其他引人注目的特性。在这里，我们报告的京尼平交联明胶和多巴胺功能化的聚（乙二醇）组成的水凝胶应变传感器在体内监测心脏功能。通过仅在其电阻范围（>10 kHz）中测量其阻抗，滞后减少，并且所得的计量因子分别从PEG-多巴和京尼平交联明胶的约0.03-0.05增加约50倍至1.02±0.05和1.46±0.05。研究粘附和体内生物相容性，以支持应变传感器在猪模型中监测心输出量的实施。千赫范围内基于阻抗的应变传感简化了这些材料的压阻行为，并扩展了基于水凝胶的应变传感器的范围。
Hydrogels are promising materials for soft and implantable strain sensors owing to their large compliance (E500%) compared to other polymer networks. Further, hydrogels can be functionalized to seamlessly integrate with many types of tissues. However, most current methods attempt to imbue additional electronic functionality to structural hydrogel materials by incorporating fillers with orthogonal properties such as electronic or mixed ionic conduction. Although composite strategies may improve performance or facilitate heterogeneous integration with downstream hardware, composites complicate the path for regulatory approval and may compromise the otherwise compelling properties of the underlying structural material. Here we report hydrogel strain sensors composed of genipin-crosslinked gelatin and dopamine-functionalized poly(ethylene glycol) for in vivo monitoring of cardiac function. By measuring their impedance only in their resistive regime (>10 kHz), hysteresis is reduced and the resulting gauge factor is increased by ~50x to 1.02±0.05 and 1.46±0.05 from approximately 0.03-0.05 for PEG-Dopa and genipin-crosslinked gelatin respectively. Adhesion and in vivo biocompatibility are studied to support implementation of strain sensors for monitoring cardiac output in porcine models. Impedance-based strain sensing in the kilohertz regime simplifies the piezoresistive behavior of these materials and expands the range of hydrogel-based strain sensors.