The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus
The Ratio of Oxidized Lipoprotein(a) to Native Lipoprotein(a) and the Endothelial Function in Patients with Type 2 Diabetes Mellitus
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DOI：
10.3390/ijms20194909
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发表时间：
2019-10-01
影响因子：
5.6
通讯作者：
Yamada, Toshiyuki
中科院分区：
文献类型：
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作者：
Kotani, Kazuhiko;Yamada, Shingo;Yamada, Toshiyuki
氧化型脂蛋白（a）/天然型脂蛋白（a）比值（oxLp（a）/Lp（a））可作为评价2型糖尿病（T2 DM）内皮功能障碍的一个合理指标。本研究使用新开发的装置Endo-PAT（TM）在T2 DM患者中调查oxLp（a）/Lp（a）水平是否与内皮功能相关。本研究共入组了63例T2 DM患者（平均年龄：59岁）。采用酶联免疫吸附法测定患者血清Lp（a）和oxLp（a）水平。使用Endo-PAT（TM）2000测量反应性充血指数（RHI）水平。进行了测量变量之间的相关性分析。在这些患者中，平均血红蛋白A1 c为7.8%。oxLp（a）/Lp（a）的中位数为0.28（四分位数范围：0.07-0.54），平均RHI为1.8（标准差：0.4）。在多元线性回归分析中，oxLp（a）/Lp（a）水平是RHI水平的独立、显著和反向变量（beta =-0.26，p < 0.05），沿着男性性别。高oxLp（a）/Lp（a）水平可能反映了T2 DM患者的内皮功能障碍，如Endo-PAT（TM）所评估。进一步的研究是必要的，以确认观察到的结果。
The ratio of oxidized lipoprotein(a) to native lipoprotein(a) (oxLp(a)/Lp(a)) may be a reasonable index for assessing endothelial dysfunction in type 2 diabetes mellitus (T2DM). The present study investigated whether the oxLp(a)/Lp(a) level is correlated with the endothelial function using the Endo-PAT(TM), a newly developed device, in patients with T2DM. A total of 63 patients with T2DM (mean age: 59 years old) were enrolled in the study. The patients' serum Lp(a) and oxLp(a) levels were measured using an enzyme-linked immunosorbent assay. The reactive hyperemia index (RHI) level was measured using an Endo-PAT(TM) 2000. A correlation analysis between the measured variables was conducted. Among the patients, the mean hemoglobin A1c was 7.8%. The median level of oxLp(a)/Lp(a) was 0.28 (interquartile range: 0.07-0.54), and the mean RHI was 1.8 (standard deviation: 0.4). In a multiple linear regression analysis, the oxLp(a)/Lp(a) level was an independent, significant, and inverse variable for the RHI level (beta = -0.26, p < 0.05), along with male gender. A high oxLp(a)/Lp(a) level may reflect endothelial dysfunction, as assessed by the Endo-PAT(TM), in patients with T2DM. Further studies are warranted to confirm the observed findings.