APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: A Longitudinal Study
APOE Genotypes and Brain Imaging Classes in Normal Cognition, Mild Cognitive Impairment, and Alzheimer's Disease: A Longitudinal Study
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DOI：
10.2174/1567205017666201109093314
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发表时间：
2020-01-01
影响因子：
2.1
通讯作者：
Camarda, Rosolino
中科院分区：
文献类型：
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作者：
Camarda, Cecilia;Torelli, Paola;Camarda, Rosolino
目的：在一项长期前瞻性研究（11.54 +/- 1.47 岁）中评估 419 名年龄 45-82 岁的无中风认知正常受试者 (CN) 的临床前至痴呆谱：1) 小血管疾病 (V) 和脑萎缩 (A) 的分布汇总如下：V-/A-、V-/A+、V+/A-、V+/A+； 2) 这些成像类别与个体载脂蛋白E (APOE) 基因型的关系； 3) 个体 APOE 基因型进展为阿尔茨海默病 (AD) 的风险。方法：参与者接受了一项基线 (t0) 和 4 项临床和神经心理学评估（t1、t2、t3 和 t4）。在 t0、t2、t3 和 t4 对所有受试者进行脑 MRI。通过两个视觉评级量表评估白质高信号。还对腔隙进行了评级。皮层下和全脑萎缩分别通过双尾状核比率和侧脑室与大脑比率来确定。在t0时确定所有受试者的APOE基因型。采用Cox比例风险模型评估进展为AD的风险。结果：混合型影像学类型在AD以及非遗忘性轻度认知障碍APOE epsilon 4非携带者中非常常见。在这些受试者中，额叶和顶枕区受小血管疾病的影响最大。结论：我们的研究结果表明 APOE epsilon 3 等位基因可能与脑血管病理有关。
Objective: To evaluate in 419 stroke-free cognitively normal subjects (CN) aged 45-82 years covering during a long prospective study (11.54 +/- 1.47 years) the preclinical to dementia spectrum: 1) the distribution of small vessel disease (V) and brain atrophy (A) aggregated as following: V-/A-, V-/A+, V+/A-, V+/A+; 2) the relationship of these imaging classes with individual apolipoprotein E (APOE) genotypes; 3) the risk of progression to Alzheimer Disease (AD) of the individual APOE genotypes.Methods: Participants underwent one baseline (t0), and 4 clinical and neuropsychological assessments (t1,t2,t3, and t4). Brain MRI was performed in all subjects at t0, t2, t3 and t4.. White matter hyperintensities were assessed through two visual rating scales. Lacunes were also rated. Subcortical and global brain atrophy were determined through the bicaudate ratio and the lateral ventricle to brain ratio, respectively. APOE genotypes were determined at tO in all subjects. Cox proportional hazard model was used to evaluate the risk of progression to AD.Results: The imaging class of mixed type was very common in AD, and in non amnestic mild cognitive impaired APOE epsilon 4 non carriers. In these subjects, frontal and parieto-occipital regions were most affected by small vessel disease.Conclusion: Our findings suggest that the APOE epsilon 3 allele is probably linked to the brain vascular pathology.