Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis
Mammary epithelial cell: Influence of extracellular matrix composition and organization during development and tumorigenesis
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DOI：
10.1016/j.biocel.2007.06.025
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
Weaver, Valerie M.
中科院分区：
文献类型：
--
作者：
Kass, Laura;Erler, Janine T.;Weaver, Valerie M.
基质-上皮相互作用调节乳腺发育，对维持组织稳态至关重要。细胞外基质是基质的一种蛋白质成分，通过一系列跨膜受体调节乳腺上皮的生长、存活、迁移和分化，其中整合素是最具特征的。整合素通过在细胞和细胞外基质之间相互传递生化和生物物理信号来调节细胞命运，促进胚胎分支形态发生和乳腺泌乳等过程。在乳房发育和癌症进展过程中，细胞外基质发生了动态变化，其组成、周转、加工和取向发生了巨大变化。这些修饰影响乳腺上皮细胞的形状，调节生长因子和激素反应，从而调节分支形态发生和肺泡分化等过程。乳腺恶性转化还与显著的基质重塑和间质进行性硬化相关，可促进乳腺上皮细胞生长，扰乱乳腺组织组织，促进细胞侵袭和存活。在这篇综述中，我们讨论了基质-上皮相互作用在正常和恶性乳腺上皮细胞行为中的作用。我们特别关注细胞外基质的生化和生物物理特性的动态调节如何通过跨膜整合素受体引发与乳腺上皮的对话，从而影响组织形态发生、稳态和恶性转化。
Stromal-epithelial interactions regulate mammary gland development and are critical for the maintenance of tissue homeostasis. The extracellular matrix, which is a proteinaceous component of the stroma, regulates mammary epithelial growth, survival, migration and differentiation through a repertoire of transmembrane receptors, of which integrins are the best characterized. Integrins modulate cell fate by reciprocally transducing biochemical and biophysical cues between the cell and the extracellular matrix, facilitating processes such as embryonic branching morphogenesis and lactation in the mammary gland. During breast development and cancer progression, the extracellular matrix is dynamically altered such that its composition, turnover, processing and orientation change dramatically. These modifications influence mammary epithelial cell shape, and modulate growth factor and hormonal responses to regulate processes including branching morphogenesis and alveolar differentiation. Malignant transformation of the breast is also associated with significant matrix remodeling and a progressive stiffening of the stroma that can enhance mammary epithelial cell growth, perturb breast tissue organization, and promote cell invasion and survival. In this review, we discuss the role of stromal-epithelial interactions in normal and malignant mammary epithelial cell behavior. We specifically focus on how dynamic modulation of the biochemical and biophysical properties of the extracellular matrix elicit a dialogue with the mammary epithelium through transmembrane integrin receptors to influence tissue morphogenesis, homeostasis and malignant transformation.