ANALYSIS OF MYOCARDIAL EDEMA BY MAGNETIC-RESONANCE-IMAGING EARLY AFTER CORONARY-ARTERY OCCLUSION WITH OR WITHOUT REPERFUSION
ANALYSIS OF MYOCARDIAL EDEMA BY MAGNETIC-RESONANCE-IMAGING EARLY AFTER CORONARY-ARTERY OCCLUSION WITH OR WITHOUT REPERFUSION
复制标题
DOI：
10.1093/cvr/27.8.1462
复制
发表时间：
1993-08-01
影响因子：
10.8
通讯作者：
SOLERSOLER, J
中科院分区：
文献类型：
--
作者：
GARCIADORADO, D;OLIVERAS, J;SOLERSOLER, J
目的：目的是分析磁共振（MR）成像参数与冠状动脉闭塞后早期心肌含水量的关系。方法：猪21只。在冠状动脉闭塞78分钟（n=7）或冠状动脉闭塞48分钟和再灌注30分钟（n=14）后，切除心脏。在再灌注方案中的7只动物中，在冠状动脉闭塞后5分钟开始，用缺氧缓冲液灌注风险区域5分钟。采用1.5T磁共振成像仪，从心尖到基底获得心脏的系列T2加权和密度加权图像。在对照和高危心肌样本中测量水含量，并在磁共振图像的相应区域测量弛豫参数。结果如下：对照组心肌含水量为399（SEM 2）ml. 100 g-1干组织，缺血心肌含水量为427（8）ml. 100 g-1干组织，再灌注心肌含水量为511（8）ml. 100 g-1干组织（p
Objective: The aim was to analyse the relationship between magnetic resonance (MR) imaging parameters and myocardial water content early after coronary occlusion with or without reperfusion. Methods: 21 pigs were used. After 78 min of coronary occlusion (n=7) or 48 min of coronary occlusion and 30 min of reperfusion (n=14) the heart was excised. In seven animals in the reperfusion protocol the area at risk was perfused for 5 min with an anoxic buffer, starting 5 min after coronary occlusion. Serial T2 weighted and density weighted images of the heart were obtained from apex to base, by using a 1.5 tesla magnetic resonance imager. Water content was measured in samples from control and at-risk myocardium and relaxation parameters were measured in corresponding areas of the magnetic resonance images. Results: Water content was 399(SEM 2) ml.100 g-1 dry tissue in control myocardium, 427(8) in ischaemic myocardium, and 511(8) in reperfused myocardium (p