Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients
Cortical microinfarcts on 3T MRI: Clinical correlates in memory-clinic patients
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DOI：
10.1016/j.jalz.2014.12.010
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发表时间：
2015-12-01
影响因子：
14
通讯作者：
Chen, Christopher
中科院分区：
文献类型：
--
作者：
van Veluw, Susanne J.;Hilal, Saima;Chen, Christopher
简介：这是第一个研究，以评估脑微梗死（CMI）3特斯拉（3 T）磁共振成像（MRI）在记忆clinic population.Methods：我们包括238例连续患者（年龄72.5 +/- 9.1岁）从记忆诊所在新加坡。所有患者在同一天接受了广泛的神经和神经心理学测试以及3 T MRI。皮质CMI评级标准改编自先前的7 T MRI研究。我们分析的频率和关联的皮质CMI与人口，临床，认知，和其他MRI findings.Results：75例（32%）有皮质CMI（中位数1，范围1-43）。CMI患者在MMSE、语言和视觉结构领域的认知功能较差。CMI的存在与其他小血管疾病的标志物有关，但最强烈的是较大的皮质梗死。脑梗死患者更经常被诊断为血管性dementia.Discussion：皮质脑梗死对3 T MRI是一种新的标记脑血管疾病的痴呆。(C)2015年，阿尔茨海默氏症协会。爱思唯尔公司出版All rights reserved.
Introduction: This is the first study to assess cerebral microinfarcts (CMIs) on 3 tesla (3T) magnetic resonance imaging (MRI) in a memory clinic population.Methods: We included 238 consecutive patients (aged 72.5 +/- 9.1 years) from a memory clinic in Singapore. All patients underwent extensive neurological and neuropsychological testing and 3T MRI on the same day. Cortical CMI rating criteria were adapted from a previous study on 7T MRI. We analyzed the frequency and association of cortical CMIs with demographic, clinical, cognition, and other MRI findings.Results: Seventy-five patients (32%) had cortical CMIs (median 1, range 1-43). Patients with CMIs showed worse cognitive functioning on MMSE, and in the domains of language and visuoconstruction. The presence of CMIs was related to other markers of small vessel disease, but most strongly larger cortical infarcts. Patients with CMIs were more often diagnosed with vascular dementia.Discussion: Cortical CMIs on 3T MRI are a novel marker of cerebrovascular disease in dementia. (C) 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.