Catalytic, Enantioselective Synthesis of α-Aminonitriles with a Novel Zirconium Catalyst.
Catalytic, Enantioselective Synthesis of α-Aminonitriles with a Novel Zirconium Catalyst.
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DOI：
10.1002/(sici)1521-3773(19981204)37:22
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发表时间：
1998-12
影响因子：
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通讯作者：
H. Ishitani;Susumu Komiyama;S. Kobayashi
中科院分区：
文献类型：
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作者：
H. Ishitani;Susumu Komiyama;S. Kobayashi
在新型手性锆双核催化剂1的存在下，醛亚胺与Bu 3 SnCN的Strecker反应以良好的产率和高的对映选择性生成α-氨基腈.该反应可应用于广泛的底物。由于手性源的两种对映异构体都容易获得，因此根据该方法容易制备α-氨基腈的两种对映异构体。L= N-甲基咪唑。
Strecker reactions of aldimines with Bu3 SnCN in the presence of the novel chiral zirconium binuclear catalyst 1 provide α-aminonitriles in good yields and with high enantioselectivities. The reaction can be applied to a wide range of substrates. Since both enantiomers of the chiral sources are readily avaibable, both enantiomers of the α-aminonitriles are easily prepared according to this method. L=N-methylimidazole.