TOPOGRAPHIC ORGANIZATION OF CONNECTIONS BETWEEN THE MAIN OLFACTORY-BULB AND PARS EXTERNA OF THE ANTERIOR OLFACTORY NUCLEUS IN THE HAMSTER
TOPOGRAPHIC ORGANIZATION OF CONNECTIONS BETWEEN THE MAIN OLFACTORY-BULB AND PARS EXTERNA OF THE ANTERIOR OLFACTORY NUCLEUS IN THE HAMSTER
复制标题
DOI：
10.1002/cne.902270113
复制
发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
MACRIDES, F
中科院分区：
文献类型：
--
作者：
SCHOENFELD, TA;MACRIDES, F
用麦芽凝集素-辣根过氧化物酶作为顺行和逆行神经元示踪剂，研究了金黄地鼠嗅球主部和嗅前核外部之间的联系组织。延髓的PE传出仅投射到对侧的神经节。在这些传出中，地形组织是明显的，这样，不同的PE部分主要投射到对侧暴徒的某些部分，少量投射到其他部分。到冠状平面上的任何球部的主要投影在几乎所有的吻尾水平上重复，即，到对侧MOG的Pe传出终止于长条或楔形内，显示相对于MOB的内侧-外侧和背腹轴的扇区到扇区的地形组织，而不是相对于MOB的嘴-尾轴。在同侧暴徒中出现的PE的传入也显示出一种扇区到扇区的地形组织。向Pe周围的限制性区段注入标记同侧MOB的限制性区段内的所有类型的输出神经元(二尖瓣细胞和内、中、外簇状细胞)，具有逆行神经元标记的区段与对侧MOB具有密集顺行终末标记的区段同源。外部簇生细胞没有标记，在尾侧向Pe注射的情况下，其他类别的MOB输出神经元没有显著的标记局部模式。投射到Pe的外部丛生细胞的胞体主要位于肾小球层的深层；大多数位于肾小球层较浅的外部丛生细胞似乎没有暴徒的外部投射。这些结果表明，Pe与MOB的传入和传出联系都是按地形图组织的，并在两个主要嗅球的同源区段之间提供了一条短的突触通路。
The organization of connections between the main olfactory bulb (MOB) and pars externa (pE) of the anterior olfactory nucleus was studied in hamsters by using wheat germ agglutinin-horseradish peroxidase as both an anterograde and a retrograde neuronal tracer. Bulbar efferents of pE project exclusively to the contralateral MOB. A topographic organization is evident in these efferents, such that distinct sectors of pE project predominantly to certain sectors of the contralateral MOB and lightly to other sectors. The predominant projection to any bulbar sector in the coronal plane is repeated at nearly all rostral-caudal levels, i.e., the pE efferents to the contralateral MOB terminate within long strips or wedges that show a sector-to-sector topographic organization with respect to the medial-lateral and dorsal-ventral axes, but not the rostal-caudal axis of the MOB. Afferents to pE arising in the ipsilateral MOB also show a sector-to-sector topographic organization. Injections into restricted sectors along the circumference of pE label all classes of output neurons (mitral cells and internal, middle and external tufted cells) in restricted sectors of the ipsilateral mOB, and the sectors that have retrograde neuronal labeling are homotopic to those in the contralateral MOB that have dense anterograde terminal labeling. External tufted cells are not labeled and the other classes of MOB output neurons do not have prominent topographic patterns of labeling in cases with injections caudal to pE. The somata of external tufted cells that project to pE are predominantly in the deep part of the glomerular layer; most of the external tufted cells that lie more superficially in the glomerular layer do not appear to have projections extrinsic to the MOB. These results indicate that both the afferent and efferent connections of pE with the MOB are topographically organized and provide a short synaptic pathway between homotopic sectors of the 2 main olfactory bulbs.