Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD
Impaired Glucose and Insulin Homeostasis in Moderate-Severe CKD
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DOI：
10.1681/asn.2015070756
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发表时间：
2016-09-01
影响因子：
13.6
通讯作者：
Utzschneider, Kristina
中科院分区：
文献类型：
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作者：
de Boer, Ian H.;Zelnick, Leila;Utzschneider, Kristina
肾脏疾病会导致临床相关的葡萄糖和胰岛素稳态紊乱，但中重度 CKD 的病理生理学仍不完全明确。在一项对 59 名非糖尿病 CKD 参与者（平均 eGFR = 37.6 ml/min 每 1.73 m(2)）和 39 名健康对照受试者的横断面研究中，我们使用高胰岛素-正常血糖钳夹以及静脉和口服葡萄糖耐量试验量化了胰岛素敏感性、清除率、分泌和葡萄糖耐量。患有 CKD 的参与者的胰岛素敏感性低于未患有 CKD 的参与者（平均值[SD] 3.9[2.0] vs 5.0 [2.0] mg/min/mu U/ml；P
Kidney disease leads to clinically relevant disturbances in glucose and insulin homeostasis, but the pathophysiology in moderate-severe CKD remains incompletely defined. In a cross-sectional study of 59 participants with nondiabetic CKD (mean eGFR =37.6 ml/min per 1.73 m(2)) and 39 healthy control subjects, we quantified insulin sensitivity, clearance, and secretion and glucose tolerance using hyperinsulinemic-euglycemic clamp and intravenous and oral glucose tolerance tests. Participants with CKD had lower insulin sensitivity than participants without CKD (mean[SD] 3.9[2.0] versus 5.0 [2.0] mg/min per mu U/ml; P