Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer
Expression of HOXD3 correlates with shorter survival in patients with invasive breast cancer
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DOI：
10.1007/s10585-012-9524-y
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发表时间：
2013-02-01
影响因子：
4
通讯作者：
Zhang Qingyuan
中科院分区：
文献类型：
--
作者：
Cheng Shaoqiang;Zhang Yue;Zhang Qingyuan
HOX基因编码一个含有同源结构域的转录因子家族，这些转录因子在发育过程中决定细胞的身份，并且在某些类型的癌症中也有表达。Hoxd3基因是Hox基因家族的成员之一，已被证明在多种肿瘤细胞系中表达，这些肿瘤细胞系通过协调表达转移相关因子而表现出更强的侵袭和转移能力。然而，Hoxd3对乳腺癌的临床影响仍不清楚。在本研究中，我们用免疫组织化学方法检测了浸润性乳腺癌组织中Hoxd3和整合素β3的表达。我们发现Hoxd3在高组织病理分级和激素受体阴性的乳腺癌患者中的表达显著增加。Hoxd3的表达与整合素β3的表达密切相关。此外，Hoxd3在乳腺肿瘤中高表达的患者比Hoxd3在乳腺肿瘤中弱表达的患者的生存期显著缩短。单变量和多变量分析证实，Hoxd3表达增加是预测乳腺癌患者预后不良的一个独立且重要的因素。总之，Hoxd3的表达是浸润性乳腺癌患者的一个重要的不良预后因素，因此是一个潜在的有用的乳腺癌预后标志物。
Hox genes encode a family of homeodomain-containing transcription factors that determine cellular identity during development and which are also expressed in some types of cancer. The HOXD3 gene, a member of the Hox gene family, has been demonstrated to be expressed in several tumor cell lines, which exhibit enhanced invasion and metastasis through coordinate expression of metastasis-associated factors. However, the clinical impact of HOXD3 in breast cancer remains unclear. In the current study, we examined the expression of HOXD3 and integrin beta 3 by immunohistochemical staining in patients with invasive breast cancer. We found that HOXD3 expression was significantly frequent in high histopathological grade and hormone-receptor negative breast cancer patients. The expression of HOXD3 was closely associated with integrin beta 3 expression. Furthermore, patients with high HOXD3 expression levels in their breast tumors had significantly shorter survival times than patients in which HOXD3 was weakly expressed in breast tumors. Univariate and multivariate analyses confirmed that increased HOXD3-expression was an independent and significant factor in predicting poor prognosis for patients with breast cancer. In conclusion, HOXD3 expression is a significant unfavorable prognostic factor for patients with invasive breast cancer and as such is a potentially useful prognostic marker for breast cancer.