Organization of inhibitory frequency receptive fields in cat primary auditory cortex
Organization of inhibitory frequency receptive fields in cat primary auditory cortex
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DOI：
10.1152/jn.1999.82.5.2358
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发表时间：
1999-11-01
影响因子：
2.5
通讯作者：
Loftus, WC
中科院分区：
文献类型：
--
作者：
Sutter, ML;Schreiner, CE;Loftus, WC
猫初级听皮层抑制性频率感受野的组织结构。神经生理学杂志。82：2358-2371，1999年。基于兴奋性频率（频谱）感受野（esRFs）的特性，以往的研究表明猫初级听觉皮层（A1）由功能不同的背侧和腹侧亚区组成。背侧A1（A1 d）被认为参与分析复杂的频谱模式，而腹侧A1（A1 v）似乎更适合分析窄带声音。然而，这些研究都是基于单音刺激，并没有考虑如何调节神经元对音调的反应时，音调是一个更复杂的声学环境的一部分。在视觉和外周听觉系统中，esRF之外的刺激成分可以对反应产生强烈的调节作用。我们研究了猫A1中单个神经元中纯音esRF之外的抑制频率区域的组织。我们发现了高发病率的抑制反应区（在95%的采样神经元）和各种各样的抑制带的结构，从一个单一的频带到超过四个不同的抑制区域。与大多数纤维具有两个周围的“横向”抑制带的听神经不同，只有38%的A1细胞具有这种简单的结构。在这个意义上，横向一词被定义为延伸到esRF的低频和高频边界之外的抑制或抑制。A1区抑制性RF结构的分布存在明显的区域差异。在Aid中，只有16%的细胞具有简单的两条带侧向RF组织，而50%的A1 v细胞具有这种组织。这种非hemogeneous地形分布的抑制特性是一致的假设，A1是由至少两个功能不同的细分，可能是不同的听觉皮层处理流的一部分。
Organization of inhibitory frequency receptive fields in cat primary auditory cortex. J. Neurophysiol. 82: 2358-2371, 1999. Based on properties of excitatory frequency (spectral) receptive fields (esRFs), previous studies have indicated that cat primary auditory cortex (A1) is composed of functionally distinct dorsal and ventral subdivisions. Dorsal A1 (A1d) has been suggested to be involved in analyzing complex spectral patterns, whereas ventral A1 (A1v) appears better suited for analyzing narrowband sounds. However, these studies were based on single-tone stimuli and did not consider how neuronal responses to tones are modulated when the tones are part of a more complex acoustic environment. In the visual and peripheral auditory systems, stimulus components outside of the esRF can exert strong modulatory effects on responses. We investigated the organization of inhibitory frequency regions outside of the pure-tone esRF in single neurons in cat A1. We found a high incidence of inhibitory response areas (in 95% of sampled neurons) and a wide variety in the structure of inhibitory bands ranging from a single band to more than four distinct inhibitory regions. Unlike the auditory nerve where most fibers possess two surrounding "lateral" suppression bands, only 38% of A1 cells had this simple structure. The word lateral is defined in this sense to be inhibition or suppression that extends beyond the low- and high-frequency borders of the esRF. Regional differences in the distribution of inhibitory RF structure across A1 were evident. In Aid, only 16% of the cells had simple two-banded lateral RF organization, whereas 50% of A1v cells had this organization. This nonhemogeneous topographic distribution of inhibitory properties is consistent with the hypothesis that A1 is composed of at least two functionally distinct subdivisions that may be part of different auditory cortical processing streams.