DIAGNOSING BACTERIAL RESPIRATORY-INFECTION BY BRONCHOALVEOLAR LAVAGE
DIAGNOSING BACTERIAL RESPIRATORY-INFECTION BY BRONCHOALVEOLAR LAVAGE
复制标题
DOI：
10.1093/infdis/155.5.862
复制
发表时间：
1987-05-01
影响因子：
6.4
通讯作者：
JONES, JM
中科院分区：
文献类型：
--
作者：
KAHN, FW;JONES, JM
我们前瞻性地评估了75例患者的纤维支气管镜检查和支气管肺泡灌洗（BAL）的细菌性下呼吸道感染的存在。对BAL标本进行需氧菌定量培养，并获得BAL细胞群的细胞分类。在18名没有呼吸道感染证据的“对照”患者中，BAL样本中存在> 1%的鳞状上皮细胞（SEC）准确地预测了样本被口咽植物群严重污染的存在。在剩余的潜在感染患者中，多形核白细胞很容易被识别，18例细菌感染患者中有16例的潜在下呼吸道病原体浓度> 105个菌落形成单位（cfu）/ml（在他们的BAL样本中没有> 1%的SEC）。没有患者没有细菌感染的证据，1%的SEC在BAL培养物中具有> 105 cfu/ml。这些研究确立了BAL技术诊断细菌性呼吸道感染的能力。
We prospectively evaluated 75 patients by fiber-optic bronchoscopy and bronchoalveolar lavage (BAL) for the presence of bacterial lower-respiratory-tract infection. BAL specimens were cultured quantitatively for aerobic bacteria, and a cell differential was obtained of the BAL cell population. In 18 "control" patients without evidence of respiratory infection, the presence of > 1% squamous epithelial cells (SECs) in the BAL sample accurately predicted the presence of heavy contamination of the sample by oropharyngeal flora. In the remaining "study" patients with potential infection, polymorphonuclear leukocytes were readily identified, and potential lower-respiratory-tract pathogens were recovered in concentrations > 105 colony-forming units (cfu) per milliliter in 16 of 18 patients with bacterial infection (none had > 1% SECs in their BAL sample). No patients without evidence of bacterial infection and with .ltoreq. 1% SECs had > 105 cfu/ml in BAL cultures. These studies establish the ability of BAL techniques to diagnose bacterial respiratory infection.