A morphogenetic regulatory role for ethyl alcohol in Candida albicans
A morphogenetic regulatory role for ethyl alcohol in Candida albicans
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DOI：
10.1111/j.1439-0507.2010.02002.x
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发表时间：
2011-11-01
期刊：
影响因子：
4.9
通讯作者：
Karuppayil, S. Mohan
中科院分区：
文献类型：
--
作者：
Chauhan, Nitin M.;Raut, Jayant S.;Karuppayil, S. Mohan
据报道，在白色念珠菌中，通过产生异戊醇、2-苯乙醇、1-十二醇、E-橙花醇和法尼醇等化学信号分子来调节形态发生。本研究主要研究乙醇对白色念珠菌的二型性和生物膜发育的影响。乙醇以浓度依赖的方式抑制四种标准诱导剂诱导的芽管形成。芽管抑制浓度(4%)对白念珠菌细胞的生长和活力无影响。乙醇对胚管的伸长也有抑制作用。4%的乙醇显著抑制聚苯乙烯和硅胶表面生物膜的形成。我们认为乙醇具有潜在的形态发生调节作用，可能影响传播、毒力和感染的建立。
Regulation of morphogenesis through the production of chemical signalling molecules such as isoamyl alcohol, 2-phenylethyl alcohol, 1-dodecanol, E-nerolidol and farnesol is reported in Candida albicans. The present study focuses on the effect of ethyl alcohol on C. albicans dimorphism and biofilm development. Ethyl alcohol inhibited germ tube formation induced by the four standard inducers in a concentration-dependent manner. The germ tube inhibitory concentration (4%) did not have any effect on the growth and viability of C. albicans cells. Ethyl alcohol also inhibited the elongation of germ tubes. Four percentage of ethyl alcohol significantly inhibited biofilm development on polystyrene and silicone surfaces. We suggest a potential morphogenetic regulatory role for ethyl alcohol, which may influence dissemination, virulence and establishment of infection.