The visfatin gene is associated with glucose and lipid metabolism in a Chinese population
The visfatin gene is associated with glucose and lipid metabolism in a Chinese population
复制标题
内脂素基因与中国人群的葡萄糖和脂质代谢相关。
DOI：
10.1111/j.1464-5491.2006.01909.x
复制
发表时间：
2006-09-01
影响因子：
3.5
通讯作者：
Luo, M.
中科院分区：
文献类型：
--
作者：
Jian, W. -X.;Luo, T. -H.;Luo, M.
AIMS Visfatin是一种新发现的脂肪因子，在内脏脂肪中含量丰富。它能降低人类和小鼠的血糖。本研究探讨血浆内脂素水平与遗传性单核苷酸多态性(SNPs)和2型糖尿病(T2 DM)及人体测量和代谢参数的关系。方法对241例40岁以上的初诊T2 DM患者、糖调节受损(IGR)患者和糖耐量正常者进行口服葡萄糖耐量试验(OGTT)和血浆胰岛素、血脂及血清内脂素的生化检测。采用等位基因特异性实时荧光定量聚合酶链式反应技术，对-1535C/T、rs2058539和rs10953502等位基因座进行基因分型。然而，肥胖者内脂素水平显著低于正常体重受试者(13.66+/-0.87比15.46+/-0.47 ng/ml，P=0.03)。男性内脂素水平与体重指数(r=-0.17，P=0.07)、腰臀比(r=0.16，P=0.08)呈显著正相关，而女性与内脂素水平无相关性。在T2 DM、IGR和正常糖耐量人群中，3个SNP位点的等位基因频率和常见单倍型频率相似。然而，这三个SNP位点与OGTT后0分钟和120分钟的血糖浓度、血糖反应曲线下面积、甘油三酯和总胆固醇水平显著相关。结论血清内脂素水平可能与男性内脏肥胖症有关，内脂素基因可能是中国人群糖脂参数变化的原因之一。
Aims Visfatin is a newly discovered adipokine found in abundance in visceral fat. It lowers plasma glucose in humans and mice. In this study, we explored the relationships between the plasma level of visfatin and genetic single nucleotide polymorphisms (SNPs) and Type 2 diabetes mellitus (T2DM) and anthropometric and metabolic parameters in Chinese subjects.Methods Oral glucose tolerance tests (OGTT) and biochemical assays for plasma insulin, lipid profiles and serum visfatin were performed in 241 newly diagnosed T2DM patients, subjects with impaired glucose regulation (IGR), and normal glucose tolerant subjects more than 40 years of age. Genotyping for three SNP loci: -1535C/T, rs2058539 and rs10953502 were performed using the allele-specific real-time PCR method.Results Visfatin levels were similar in T2DM patients, IGR and normal glucose tolerant subjects. However, visfatin levels were significantly lower in obese than normal-weight subjects (13.66 +/- 0.87 vs. 15.46 +/- 0.47 ng/ml, P = 0.03). There was suggestively significant correlation between visfatin level and body mass index (r = -0.17 P = 0.07) and waist-hip ratio (r = 0.16 P = 0.08) in male subjects, but not in female subjects. Allele and common haplotype frequencies of the three SNP loci were similar in T2DM patients, IGR and normal glucose tolerant subjects. However, significant associations were found between these three SNP loci and plasma glucose concentration at 0 and 120 min during OGTT, the area under the response curve for plasma glucose, and triglyceride and total cholesterol levels.Conclusions Serum visfatin levels may be related to visceral obesity in men, and the visfatin gene may account for variation of glucose and lipid parameters in Chinese subjects.