Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue.
Transglutaminase autoantibodies in dermatitis herpetiformis and celiac sprue.
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疱疹样皮炎和乳糜泻中的转谷氨酰胺酶自身抗体。
DOI：
10.1038/sj.jid.5701041
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Murray,JosephA
中科院分区：
文献类型：
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作者：
Marietta,EricV;Camilleri,MichaelJ;Castro,LuisA;Krause,PatriciaK;Pittelkow,MarkR;Murray,JosephA
疱疹样皮肤病（DH）是一种自身免疫性起泡性皮肤病，与肠麸质敏感性有关。表皮转氨酶（TGe）和密切相关的组织转氨酶（tTG）被认为是DH中的自身抗原，因为大多数DH患者具有对TGe和tTG特异性的伊加。目前尚不清楚这些自身抗原特异性IgA在DH中的何处以及如何产生。本文报道的结果9 DH患者的含麸质的饮食表明，循环中的抗tTG伊加和抗TGe伊加在DH的水平是相互相关的，这两者似乎与肠病的程度（范围）。对15名未经治疗的乳糜泻（CS）患者的分析表明，约33%的CS患者具有升高的抗TGe伊加水平。这些结果表明，肠道损伤与DH患者中抗tTG伊加和抗TGe伊加的产生有关。
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disorder that is associated with intestinal gluten sensitivity. Epidermal transglutaminase (TGe) and closely related tissue transglutaminase (tTG) are considered to be autoantigens in DH, because a majority of DH patients have IgA specific for TGe and for tTG. It is unknown where and how these autoantigen-specific IgAs are generated in DH. Results reported in this paper on nine DH patients on a gluten containing diet demonstrate that the levels of circulating anti-tTG IgA and anti-TGe IgA in DH are correlated with each other and that both appear to be correlated with the degree (extent) of enteropathy. An analysis of 15 untreated celiac sprue (CS) patients demonstrated that approximately 33% of CS patients had elevated levels of anti-TGe IgA. These results would indicate that intestinal damage is associated with the production of anti-tTG IgA and anti-TGe IgA in DH patients.