Tissue-based class control: the other side of tolerance
Tissue-based class control: the other side of tolerance
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DOI：
10.1038/nri2940
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发表时间：
2011-03-01
影响因子：
100.3
通讯作者：
Kamala, Tirumalai
中科院分区：
文献类型：
--
作者：
Matzinger, Polly;Kamala, Tirumalai
在这篇文章中，我们提供了一个关于免疫反应如何调节的新视角。我们不讨论它们是如何开启和关闭的，而是专注于免疫反应的第二个主要方面：效应器类别的控制。虽然通常认为免疫反应的类别是为适应入侵的病原体而定制的，但我们在这里建议，它主要是为了适应发生反应的组织而定制的。为此，我们涵盖了这样的主题：T辅助(T-H)细胞亚群的性质(目前和尚未发现)，特权部位的性质，口服耐受和口服疫苗之间的差异，为什么免疫途径重要，T(H)1型反应是否真的是免疫系统的主要防御，以及一些调节性T细胞是否可能有不同的作用。
In this Essay, we offer a new perspective on how immune responses are regulated. We do not cover how they are turned on and off, but focus instead on the second major aspect of an immune response: the control of effector class. Although it is generally thought that the class of an immune response is tailored to fit the invading pathogen, we suggest here that it is primarily tailored to fit the tissue in which the response occurs. To this end, we cover such topics as the nature of T helper (T-H) cell subsets (current and yet to be discovered), the nature of privileged sites, the difference between oral tolerance and oral vaccination, why the route of immunization matters, whether the T(H)1-type response is really the immune system's primary defense, and whether there might be a different role for some regulatory T cells.