The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns.
The absence of interaction between drug metabolizing enzyme genotypes and maternal lifestyle factors on glycophorin A somatic mutation frequency levels in newborns.
复制标题
药物代谢酶基因型和母亲生活方式因素对新生儿血型糖蛋白 A 体细胞突变频率水平不存在相互作用。
DOI：
10.1097/01.fpc.0000184954.08453.e1
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Romkes,Marjorie
中科院分区：
文献类型：
--
作者：
Nukui,Tomoko;Day,RichardD;Gordish-Dressman,HeatherA;Harger,Gail;Bigbee,WilliamL;Ness,RobertaB;Romkes,Marjorie
Prenatal exposure to carcinogens results in newborn DNA damage which in turn is associated with impaired health conditions in both childhood and adulthood. The present study aimed to evaluate whether phase I and II biotransformation enzyme genetic polymorphisms in combination with environmental exposures during pregnancy result in elevated levels of newborn DNA damage. Maternal peripheral and umbilical cord blood samples from 406 mother/newborn pairs were genotyped for a panel of phase I/II metabolic enzymes (CYP1A1, CYP2E1, GSTM1, GSTT1 and NAT2) responsible for the metabolism of tobacco and lifestyle-related mutagens and carcinogens. DNA damage was measured by somatic cell mutation frequency at the glycophorin A (GPA) locus in newborns. No association with elevated somatic cell mutation frequency was observed between the combination of maternal/newborn genotypes and cigarette smoke or lifestyle exposures. The observed variation in newborn GPA frequency might be due to either environmental factors not assessed in this study or inter-individual differences in alternative metabolic or DNA repair pathways.
