Impact of rhinoviruses on pediatric community-acquired pneumonia
Impact of rhinoviruses on pediatric community-acquired pneumonia
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DOI：
10.1007/s10096-011-1487-4
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发表时间：
2012-07-01
影响因子：
4.5
通讯作者：
Principi, Nicola
中科院分区：
文献类型：
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作者：
Esposito, Susanna;Daleno, Cristina;Principi, Nicola
这项研究涉及592名在急诊科就诊的经放射检查确诊的社区获得性肺炎(CAP)儿童，旨在评估鼻病毒(RV)在该病中的作用。每名儿童的呼吸道分泌物用RVP Fast进行检测，以检测17种呼吸道病毒，并对RV阳性的样本进行实时聚合酶链式反应和测序。检出RV 172例(29.0%)，其中1岁以下48例(36.3%)，1~3岁80例(27.3%)，4岁以下44例(26.3%)。测序显示A组82例(49.1%)，B组17例(10.1%)，C组52例(31.1%)，未分型21例(12.2%)。99例RV为单一病原体，73例(40.7%)与两种或两种以上其他病毒混合感染。不同RV感染组之间以及RV单独感染和混合感染之间仅有微小差异。RV CAP不仅在年龄较小的儿童中常见，而且在较大的儿童中也很常见，RV-A是与其相关的最常见的菌株。RV CAP的临床相关性似乎是轻微到中度的，在A和B株与最近发现的RV C之间没有任何重大差异。
This study of 592 children seen in our Emergency Department with radiographically confirmed community-acquired pneumonia (CAP) was designed to evaluate the role of rhinoviruses (RVs) in the disease. The respiratory secretions of each child were assayed using RVP Fast in order to detect 17 respiratory viruses, and the RV-positive samples were characterised by means of real-time polymerase chain reaction and sequencing. RVs were identified in 172 cases (29.0%): 48/132 children aged < 1 year (36.3%), 80/293 aged 1-3 years (27.3%), and 44/167 aged a parts per thousand yen4 years (26.3%). Sequencing demonstrated that 82 RVs (49.1%) were group A, 17 (10.1%) group B, and 52 (31.1%) group C; 21 (12.2%) were untyped. RVs were found as single agents in 99 cases, and together with two or more other viruses in 73 (40.7%). There were only marginal differences between the different RV groups and between single RV infection and RV co-infections. RV CAP is frequent not only in younger but also in older children, and RV-A is the most common strain associated with it. The clinical relevance of RV CAP seems to be mild to moderate without any major differences between the A and B strains and the recently identified RV C.