Genome-wide screening and identification of long noncoding RNAs and their interaction with protein coding RNAs in bladder urothelial cell carcinoma
Genome-wide screening and identification of long noncoding RNAs and their interaction with protein coding RNAs in bladder urothelial cell carcinoma
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膀胱尿路上皮细胞癌中长非编码RNA的全基因组筛选和鉴定及其与蛋白质编码RNA的相互作用
DOI：
10.1016/j.canlet.2014.03.033
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发表时间：
2014-07-10
期刊：
影响因子：
9.7
通讯作者：
Xie, Hai-Long
中科院分区：
文献类型：
--
作者：
Wang, Longxin;Fu, Dian;Xie, Hai-Long
为了了解IncRNAs在膀胱癌中的表达谱及其可能的功能，我们研究了IncRNA和编码RNA在人膀胱癌和正常膀胱组织中的表达。生物信息学分析表明，与正常膀胱组织相比，膀胱癌组织中有数千个显著差异表达的IncRNAs和编码mRNA。共表达分析表明，50%的IncRNAs和编码RNAs的表达方向相同。IncRNAs的一个子集可能参与mTOR信号、P53信号和癌症通路。本研究为IncRNA和编码RNA在膀胱癌细胞中的大规模共表达提供了实验依据，为进一步研究奠定了生物学基础。(C)2014爱思唯尔爱尔兰有限公司。保留所有权利。
To understand IncRNAs expression profiling and their potential functions in bladder cancer, we investigated the IncRNA and coding RNA expression on human bladder cancer and normal bladder tissues. Bioinformatic analysis revealed thousands of significantly differentially expressed IncRNAs and coding mRNA in bladder cancer relative to normal bladder tissue. Co-expression analysis revealed that 50% of IncRNAs and coding RNAs expressed in the same direction. A subset of IncRNAs might be involved in mTOR signaling, p53 signaling, cancer pathways. Our study provides a large scale of co-expression between IncRNA and coding RNAs in bladder cancer cells and lays biological basis for further investigation. (C) 2014 Elsevier Ireland Ltd. All rights reserved.