MUTATIONS AFFECTING TEA BLOCKADE AND ION PERMEATION IN VOLTAGE-ACTIVATED K+ CHANNELS
MUTATIONS AFFECTING TEA BLOCKADE AND ION PERMEATION IN VOLTAGE-ACTIVATED K+ CHANNELS
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DOI：
10.1126/science.2218530
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发表时间：
1990-10-12
期刊：
影响因子：
56.9
通讯作者：
YELLEN, G
中科院分区：
文献类型：
--
作者：
MACKINNON, R;YELLEN, G
电压依赖性离子通道负责神经元和其他细胞中的电信号传导。电压依赖性通道的主要类别（钠选择性通道、钙选择性通道和钾选择性通道）具有密切相关的分子结构。对于该超家族的一个成员，瞬时电压激活的 Shaker H4 钾通道，现已鉴定出特定的氨基酸残基，这些残基会影响小离子四乙铵的通道阻断以及离子通过孔的传导。此外，天然存在的钾通道中这些氨基酸位置之一的变化可能是它们对四乙铵敏感性差异的大部分原因。
Voltage-dependent ion channels are responsible for electrical signaling in neurons and other cells. The main classes of voltage-dependent channels (sodium-, calcium-, and potassium-selective channels) have closely related molecular structures. For one member of this superfamily, the transiently voltage-activated Shaker H4 potassium channel, specific amino acid residues have now been identified that affect channel blockade by the small ion tetraethylammonium, as well as the conduction of ions through the pore. Furthermore, variation at one of these amino acid positions among naturally occurring potassium channels may account for most of their differences in sensitivity to tetraethylammonium.