Serum Phosphate and Microvascular Function in a Population-Based Cohort
Serum Phosphate and Microvascular Function in a Population-Based Cohort
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DOI：
10.2215/cjn.02610319
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发表时间：
2019-11-07
影响因子：
9.8
通讯作者：
Ix, Joachim H.
中科院分区：
文献类型：
--
作者：
Ginsberg, Charles;Houben, Alfons J. H. M.;Ix, Joachim H.
背景和目的高血磷与心血管事件和全因死亡率相关。这种关联的解释集中在大血管钙化和僵硬。研究表明，较高的血清磷诱导微血管功能障碍，但在人类的关系与微血管功能的直接措施是lack.Design，设置，参与者，和measurementsWe进行了一个横断面分析3189社区生活的参与者，接受皮肤毛细血管镜，激光多普勒血流仪，闪烁光？诱发视网膜血管反应。我们使用线性回归来评估血清磷和每个微血管结果之间的关联。主要结果是毛细血管镜检查显示的闭塞后峰值反应性充血期间皮肤毛细血管的募集。次要结局包括静脉充血期间的毛细血管募集、热诱导的皮肤充血反应、闪烁光？诱导视网膜小动脉和小静脉扩张。8年，48%为女性，7%有eGFR
Background and objectivesHigher serum phosphate is associated with cardiovascular events and all-cause mortality. Explanations of this association have focused on large vessel calcification and stiffness. Studies suggest that a higher serum phosphate induces microvascular dysfunction, but relationships in humans with direct measures of microvascular function are lacking.Design, setting, participants, & measurementsWe performed a cross-sectional analysis of 3189 community-living participants that underwent skin capillaroscopy, laser-Doppler flowmetry, and flicker light?induced retinal vessel responses. We used linear regression to assess the association between serum phosphate and each microvascular outcome. The primary outcome was skin capillary recruitment during postocclusive peak reactive hyperemia by capillaroscopy. Secondary outcomes included capillary recruitment during venous congestion, heat-induced skin hyperemic response, flicker light?induced retinal arteriolar, and venular dilation.ResultsThe mean age of the cohort was 59?8 years, 48% were women, 7% had an eGFR