Antigenic similarity of toxins produced by Clostridium botulinum type C and D strains
Antigenic similarity of toxins produced by Clostridium botulinum type C and D strains
复制标题
C 型和 D 型肉毒梭菌产生的毒素的抗原相似性
DOI：
10.1128/iai.30.3.656-660.1980
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发表时间：
1980
影响因子：
3.1
通讯作者：
S. Kubo
中科院分区：
文献类型：
--
作者：
K. Oguma;B. Syuto;H. Iida;S. Kubo
抗纯化肉毒梭菌C1型毒素及其重链组分交叉中和D型毒素的抗血清。抗部分纯化D型毒素的抗血清交叉中和C1型毒素。从后者血清中，获得了仅中和D型毒素的组分和同样中和C1和D毒素的组分。我们得出结论，交叉中和不是由于C型和D型菌株产生C1和D毒素，而是由于毒素具有其分子共有的抗原。琼脂双向扩散试验结果也支持这一结论。
Antisera against purified type C1 toxin of Clostridium botulinum and its heavy-chain component cross-neutralized type D toxin. Antisera against partially purified type D toxin cross-neutralized type C1 toxin. From the latter serum, a component which neutralized only type D toxin and a component which equally neutralized both C1 and D toxins were obtained. We concluded that the cross-neutralization was not due to the fact that type C and D strains produce both C1 and D toxins but rather to the fact that the toxins have an antigen(s) common to their molecules. The results of the agar gel-double-diffusion test also supported this conclusion.