Oral and gastric input to the parabrachial nucleus of the rat
Oral and gastric input to the parabrachial nucleus of the rat
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DOI：
10.1016/s0006-8993(02)03438-8
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发表时间：
2002-12-13
期刊：
影响因子：
2.9
通讯作者：
Travers, JB
中科院分区：
文献类型：
--
作者：
Karimnamazi, H;Travers, SP;Travers, JB
孤束核（NST）向臂旁核（PBN）的投射携带来自口腔和胃肠道的传入信号。虽然生理学研究表明，在臂旁核的口腔和胃肠道的感觉信号的会聚，解剖学研究强调这些途径的分离。为了更精确地确定胃扩张和口传入代表PBN之间的解剖关系，两个顺行示踪剂的小存款在同一大鼠的生理指导下的NST。胃的终端是密集的，分开的味觉预测在嘴部的外侧和背外侧亚核。味觉投射是dennerous和分开的腹侧和中央内侧亚核的尾腰区的胃终端，但在这些亚核和外部亚核在略喙水平与胃的预测混杂。分离和重叠的模式往往出现在亚核边界内或跨亚核边界的“补丁”。在第二组实验中，生理学证据的重叠PBN进行了评价，从单一单位的细胞外反应引起的胃扩张和orosensory（味觉和orotactile）刺激。神经生理学记录证实，腰部和外部亚核内的一小部分单细胞可以被激活的胃和orotactile刺激。解剖学实验进一步揭示了核内的预测从尾部NST注射，延长吻的网站，在该网站的响应，口腔刺激已被记录。虽然现有的生理数据表明这种相互作用比PBN中的相互作用更有限，但这些解剖学数据表明胃/口腔相互作用也可能存在于NST中。(C)2002 Elsevier Science B.V.保留所有权利。
Projections to the parabrachial nucleus (PBN) from the nucleus of the solitary tract (NST) carry afferent signals from both the oral cavity and gastrointestinal tract. Although physiological studies suggest the convergence of oral and gastrointestinal sensory signals in the parabrachial nucleus, anatomical studies have emphasized the segregation of these pathways. To more precisely determine the anatomical relationship between gastric distension and oral afferent representation in PBN, small deposits of two anterograde tracers were made into the NST under physiological guidance in the same rat. Gastric terminations were dense and separate from taste projections in the rostral portion of the external lateral and dorsal lateral subnuclei. Gustatory projections were densest and separate from gastric terminations in the ventral lateral and central medial subnuclei of the caudal waist region, but were intermingled with gastric projections in these subnuclei and the external subnuclei at slightly more rostral levels. Patterns of segregation and overlap often appeared as 'patches' within or across subnuclear boundaries. In a second set of experiments, physiological evidence for overlap in PBN was evaluated from single unit extracellular responses evoked by gastric distension and orosensory (taste and orotactile) stimulation. Neurophysiological recordings verified that a small proportion of single cells within the waist and external subnuclei could be activated by both gastric and orotactile stimulation. The anatomical experiments further revealed intranuclear projections from the caudal NST injections that extended rostrally to sites at which responses to oral stimulation had been recorded. Although existing physiological data suggest such interactions are more limited than those in PBN, these anatomical data suggest that gastric/oral interactions may also exist in the NST. (C) 2002 Elsevier Science B.V. All rights reserved.