A single-neuron correlate of change detection and change blindness in the human medial temporal lobe
A single-neuron correlate of change detection and change blindness in the human medial temporal lobe
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DOI：
10.1016/j.cub.2006.08.064
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发表时间：
2006-10-24
期刊：
影响因子：
9.2
通讯作者：
Fried, Itzhak
中科院分区：
文献类型：
--
作者：
Reddy, Leila;Quiroga, Rodrigo Quian;Fried, Itzhak
当注意力没有集中在变化的位置时，观察者往往没有意识到他们的视觉环境的变化[1-4]。由于其相当有趣的性质，这种现象被称为变化盲视，已经被心理物理学[5-7]和功能磁共振成像[8-11]广泛研究。然而，是否可以在单细胞的活动中跟踪变化盲视尚不清楚。为了探讨变化检测和变化盲视的神经相关性，我们记录了人类内侧颞叶（MTL）的单个神经元在变化检测范式。当受试者正确识别变化（变化检测）时，视觉反应单元的首选图片在参加的试验中引起了显着更高的放电率，而当他们错过了变化（变化盲视）时，无人值守的试验。在正确的试验中，单个单元的发射活动使我们能够预测变化的发生，在逐个试验的基础上，准确率为67%。相比之下，这一预测是在不正确的，无人值守的试验机会。因此，视觉选择性MTL细胞的放电率构成了变化检测的神经相关性。
Observers are often unaware of changes in their visual environment when attention is not focused at the location of the change [1-4]. Because of its rather intriguing nature, this phenomenon, known as change blindness, has been extensively studied with psychophysics [5-7] as well as with fMRI [8-11]. However, whether change blindness can be tracked in the activity of single cells is not clear. To explore the neural correlates of change detection and change blindness, we recorded from single neurons in the human medial temporal lobe (MTL) during a change-detection paradigm. The preferred pictures of the visually responsive units elicited significantly higher firing rates on the attended trials when subjects correctly identified a change (change detection) compared to the unattended trials when they missed it (change blindness). On correct trials, the firing activity of individual units allowed us to predict the occurrence of a change, on a trial-by-trial basis, with 67% accuracy. In contrast, this prediction was at chance for incorrect, unattended trials. The firing rates of visually selective MTL cells thus constitute a neural correlate of change detection.