Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study
Amplitude of low-frequency fluctuation (ALFF) may be associated with cognitive impairment in schizophrenia: a correlation study
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低频波动幅度（ALFF）可能与精神分裂症认知障碍相关：一项相关研究
DOI：
10.1186/s12888-018-1992-4
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发表时间：
2019
期刊：
影响因子：
4.4
通讯作者：
Tang Yanqing
中科院分区：
文献类型：
--
作者：
Wang Pengshuo;Yang Jian;Yin Zhiyang;Duan Jia;Zhang Ran;Sun Jiaze;Xu Yixiao;Liu Luyu;Chen Xuemei;Li Huizi;Kang Jiahui;Zhu Yue;Deng Xin;Chang Miao;Wei Shengnan;Zhou Yifang;Jiang Xiaowei;Wang Fei;Tang Yanqing
背景精神分裂症（SZ）患者存在显著的认知功能障碍。影像学研究表明，SZ患者存在多个脑区的功能改变。这两个指数之间的关系在深圳很大程度上是未知的。使用MATRICS共识认知成套测验（MCCB）测量SZ患者多维认知领域的认知障碍。本研究旨在探讨SZ患者认知功能损害与低频波动幅度（ALFF）的关系。MCCB用于评估参与者的认知功能，而大脑活动则使用ALFF进行评估。MCCB和ALFF之间的关系进行了调查，通过使用相关性analysis.ResultsThere有显着差异SZ患者和HC之间的MCCB的总和域的分数，以及在ALFF的结果。SZ患者双侧中央后回和中央旁小叶ALFF的减少与MCCB符号编码分测验呈负相关。ConclusionThese findings suggest，SZ患者双侧中央后回和中央旁小叶ALFF的减少可能与认知功能障碍有关。
BackgroundCognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients.MethodA total of 104 participants (44 SZ patients and 60 age- and gender-matched healthy controls (HC)) were recruited for this study. The MCCB was used to assess cognitive function of the participants, while brain activity was assessed using the ALFF. The relationship between the MCCB and the ALFF was investigated by using a correlation analysis.ResultsThere were significant differences between SZ patients and HC in MCCB total and domain scores as well as in ALFF results. The reduction of ALFF in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MCCB sub-test of symbol coding.ConclusionThese findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients.