JNK activation mediates the apoptosis of xCT-deficient cells
JNK activation mediates the apoptosis of xCT-deficient cells
复制标题
JNK 激活介导 xCT 缺陷细胞的凋亡。
DOI：
10.1016/j.bbrc.2008.03.134
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发表时间：
2008-06-13
影响因子：
3.1
通讯作者：
Li, Wei
中科院分区：
文献类型：
--
作者：
Qiao, Hai-Xuan;Hao, Chan-Juan;Li, Wei
System X-c(-) is an anionic amino acid transport system highly specific for cystine and glutamate. The underlying mechanism of cell death of cultured cells from the subtle gray (sut) mouse which contains an xCT null mutation remains elucidated. Our results show that the death of sut cells is likely caused by apoptosis mediated by c-Jun N-terminal kinase (JNK). The JNK activation triggers both a caspase-dependent (caspases-9 and -3) and an ER stress-mediated (eIF2 and CHOP) pathway to induce apoptosis. These findings suggest the possible pathways involved in the cell death of xCT-deficient cells. (c) 2008 Elsevier Inc. All rights reserved.
