HDR Brachytherapy Planning using Active Needles - Preliminary Investigation on Dose Planning.
HDR Brachytherapy Planning using Active Needles - Preliminary Investigation on Dose Planning.
复制标题
使用主动针进行 HDR 近距离放射治疗规划 - 剂量规划的初步调查。
DOI：
10.1109/biorob52689.2022.9925426
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Konh,Bardia
中科院分区：
文献类型：
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作者：
Rabiei,Mahsa;Ko,SeongYoung;Podder,TarunK;Lederer,John;Konh,Bardia
在这项研究中，我们提出了一种新的方法来计划一个高剂量率（HDR）前列腺近距离放射治疗（BT）使用主动针最近开发的我们的小组。主动针在组织内实现双向弯曲，因此与传统直针相比更符合患者的解剖结构。提出了一种计算方法，以首先基于患者的前列腺解剖结构生成针布置配置。生成针布置以覆盖前列腺体积，从而在HDR BT期间为辐射源提供可访问通道。针布置构造避开健康器官并且防止针在体内碰撞。然后提出治疗计划，以确保足够的处方剂量到整个前列腺。将该方法应用于从匿名患者重建的前列腺模型，以显示该方法的可行性。最后，示出了主动针产生所需弯曲的能力。我们已经表明，我们的方法能够使用活动针自动生成针布置配置，并且计划满足剂量目标的治疗，同时使用比由直针执行的常规HDR BT更少的针（约为常规直针的20%）。
In this study we present a new approach to plan a high-dose-rate (HDR) prostate brachytherapy (BT) using active needles recently developed by our group. The active needles realize bi-directional bending inside the tissue, and thereby more compliant with the patient's anatomy compared with conventional straight needles. A computational method is presented to first generate a needle arrangement configuration based on the patient's prostate anatomy. The needle arrangement is generated to cover the prostate volume, providing accessible channels for the radiation source during a HDR BT. The needle arrangement configuration avoids healthy organs and prevents needle collision inside the body. Then a treatment plan is proposed to ensure sufficient prescribed dosage to the whole prostate gland. The method is applied to a prostate model reconstructed from an anonymized patient to show the feasibility of this method. Finally, the active needle's capability to generate the required bending is shown. We have shown that our method is able to automatically generate needle arrangement configuration using active needles, and plan for a treatment that meets the dose objectives while using fewer needles (about 20% of conventional straight needles) than the conventional HDR BT performed by straight needles.