Pleural Mesothelioma in New Caledonia: Associations with Environmental Risk Factors
Pleural Mesothelioma in New Caledonia: Associations with Environmental Risk Factors
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DOI：
10.1289/ehp.1002862
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发表时间：
2011-05-01
影响因子：
10.4
通讯作者：
Robineau, Bernard
中科院分区：
文献类型：
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作者：
Baumann, Francine;Maurizot, Pierre;Robineau, Bernard
背景：在新喀里多尼亚观察到恶性间皮瘤（MM）的高发病率。以前的工作已经表明MM和土壤中含有serpentinite. Competitives：我们研究了MM的空间和时间变化及其与环境factors.METHODS：我们调查了109 MM病例记录在新喀里多尼亚癌症登记处1984年和2008年之间，并进行空间，时间和时空聚类分析。我们进行了一项生态分析，涉及大面积的100个部落，包括发病率最高的部落。使用Logistic和Poisson回归分析评估与环境因素的关联。结果：最高的发病率在后爱楼地区观察到，世界年龄标准化率为128.7每10万人年[95%置信区间（CI），70.41-137.84]。一个显著的空间聚类将18个部落分组（31个观察到的病例与8个预期病例; p = 0.001），但未发现显著的时间聚类。生态分析确定道路上的蛇纹岩是最大的环境风险因素（比值比= 495.0; 95%CI，46.2-4679.7;多变量发病率比= 13.0; 95%CI，10.2-16.6）。风险随着蛇纹岩表面、蛇纹岩采石场的接近程度和橄榄岩矿脉的距离而增加。与蛇纹岩的关系比与角闪石的关系强。生活在斜坡上，靠近茂密的植被似乎起到了保护作用。使用粉刷，以前建议是一个危险因素，与MM incidence.CONCLUSIONS：蛇纹岩道路上的存在是一个主要的环境风险因素间皮瘤在新喀里多尼亚。
BACKGROUND: High incidences of malignant mesothelioma (MM) have been observed in New Caledonia. Previous work has shown an association between MM and soil containing serpentinite.OBJECTIVES: We studied the spatial and temporal variation of MM and its association with environmental factors.METHODS: We investigated the 109 MM cases recorded in the Cancer Registry of New Caledonia between 1984 and 2008 and performed spatial, temporal, and space-time cluster analyses. We conducted an ecological analysis involving 100 tribes over a large area including those with the highest incidence rates. Associations with environmental factors were assessed using logistic and Poisson regression analyses.RESULTS: The highest incidence was observed in the Houailou area with a world age-standardized rate of 128.7 per 100,000 person-years [95% confidence interval (CI), 70.41-137.84]. A significant spatial cluster grouped 18 tribes (31 observed cases vs. 8 expected cases; p = 0.001), but no significant temporal clusters were identified. The ecological analyses identified serpentinite on roads as the greatest environmental risk factor (odds ratio = 495.0; 95% CI, 46.2-4679.7; multivariate incidence rate ratio = 13.0; 95% CI, 10.2-16.6). The risk increased with serpentinite surface, proximity to serpentinite quarries and distance to the peridotite massif. The association with serpentines was stronger than with amphiboles. Living on a slope and close to dense vegetation appeared protective. The use of whitewash, previously suggested to be a risk factor, was not associated with MM incidence.CONCLUSIONS: Presence of serpentinite on roads is a major environmental risk factor for mesothelioma in New Caledonia.